Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00564 ...
Drug Name Carbamazepine
Molecular Weight 236.2686
Molecular Formula C15H12N2O
CAS Number 298-46-4
SMILES NC(=O)N1C2=CC=CC=C2C=CC2=CC=CC=C12
External Links
DRUGBANK DB00564
T3DB T3D2826
PubChem Compound 2554
PDR 1630
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.77 - 2.77 - http://www.t3db.ca/toxins/T3D2826
Boiling Point 399.6 ℃ 399.6±45.0 ℃ https://www.lookchem.com/Carbamazepine/
Melting Point 190.5 ℃ 189-192 ℃ https://www.lookchem.com/Carbamazepine/
pKa 15.96 - 15.96,-3.8 - http://www.t3db.ca/toxins/T3D2826
pKa -3.8 - 15.96,-3.8 - http://www.t3db.ca/toxins/T3D2826
Log S -3.2 - -3.2 - http://www.t3db.ca/toxins/T3D2826

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 80.0 % 75-85 % DRUGBANK
Bioavailability 70.0 % >70 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 1900.0 ng/ml 1.9±0.3 mcg/ml PO, oral; extended release formulation; DRUGBANK
C Max 11000.0 ng/ml 11.0±2.5 mcg/ml Oral multiple dose; DRUGBANK
C Max 9300.0 ng/ml 9.3(2-18) mcg/ml PO, oral; immediate release formulation; adults; epilepsy; The Pharmacological Basis of Therapeutics
T Max 19.0 h 19±7 h PO, oral; extended release formulation; DRUGBANK
T Max 5.9 h 5.9±1.8 h Oral multiple dose; DRUGBANK
T Max 6.0 h 4-8 h PO, oral; immediate release formulation; adults; epilepsy; The Pharmacological Basis of Therapeutics
Clearance 1.5 L/h 25±5 ml/min Total clearance; Oral single dose; DRUGBANK
Clearance 4.8 L/h 80±30 ml/min Total clearance; Oral multiple dose; DRUGBANK
Clearance 0.90 L/h/kg 13±0.5 ml/min/kg Children → ;Elderly → ;Preg, pregnant ↑ ;Somking → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.1 L/kg 0.7-1.4 L/kg DRUGBANK
Volume of Distribution 1.4 L/kg 1.4±0.4 L/kg Neonates → ;Children → ;Elderly → ; The Pharmacological Basis of Therapeutics
Half-life 37.5 h 35-40 h Single dose; elimination half-life; extended release formulation; DRUGBANK
Half-life 14.5 h 12-17 h Multiple dose; DRUGBANK
Half-life 31.9 h 27-36.8 h elimination half-life; normal,healthy; DRUGBANK
Half-life 15.0 h 15±5 h Oral multiple dose; Children → ;Neonates → ;Age → ; The Pharmacological Basis of Therapeutics
Toxicity LD50 1957.0 mg/kg 1957.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LDLo 228480.0 mg/kg/day 1920.0 mg/kg/17W  Female, women; DRUGBANK
Toxicity LDLo 486.0 mg/kg/day 54.0 mg/kg/9D Male, men; DRUGBANK
Eliminate Route 72.0 % 72 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 28.0 % 28 % Faeces excretion; PO, oral; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 77.5 % 75-80 % plasma proteins; DRUGBANK
Protein Binding 74.0 % 74±3 % Preg, pregnant → ;RD, renal impairment, Renal disease，including uremia → ;Hepatic cirrhosis, cirr → ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for infants 1000.0 mg/day 1000 mg/day Tablet,PO，oral Epitol carbamazepine PDR
Max dose for infants 35.0 mg/kg/day 35 mg/kg/day Tablet,PO，oral Epitol carbamazepine PDR
Max dose for infants 35.0 mg/kg/day 35 mg/kg/day Capsule, PO, Oral Epitol carbamazepine PDR
Max dose for children 1200.0 mg/day 1200 mg/day PO, oral Epitol carbamazepine PDR
Max dose for children 1000.0 mg/day 1000 mg/day PO, oral Epitol carbamazepine PDR
Max dose for adolescents 1200.0 mg/day 1200 mg/day PO, oral Epitol carbamazepine PDR
Max dose for adolescents 1600.0 mg/day 1600 mg/day PO, oral Epitol carbamazepine PDR
Max dose for adolescents 1120.0 mg/day 1120 mg/day intravenous injection, IV Epitol carbamazepine PDR
Max dose for geriatric 1200.0 mg/day 1200 mg/day PO, oral Epitol carbamazepine PDR
Max dose for geriatric 1600.0 mg/day 1600 mg/day PO, oral Epitol carbamazepine PDR
Max dose for geriatric 1120.0 mg/day 1120 mg/day intravenous injection, IV Epitol carbamazepine PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1