Basic Information
| Drug ID | DDPD00560 |
|
| Drug Name | Tigecycline | |
| Molecular Weight | 585.6487 | |
| Molecular Formula | C29H39N5O8 | |
| CAS Number | 220620-09-7 | |
| SMILES | [H][C@@]12CC3=C(C(O)=C(NC(=O)CNC(C)(C)C)C=C3N(C)C)C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2 | |
| External Links | ||
| DRUGBANK | DB00560 | |
| PubChem Compound | 54686904 | |
| PDR | 2342 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.8 | - | 0.8 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 0.23 | L/h/kg | 3.8 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 12.0 | L/kg | 12 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 35.0 | h | 27-43 | h | DRUGBANK | Half-life | 48.0 | h | 48 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 80.0 | % | 71-89 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for children | 50.0 | mg | 50 | mg | intravenous injection, IV | bid | Tygacil | tigecycline | PDR |
| Max dose for children | 2.4 | mg/kg/day | 1.2 | mg/kg/dose | intravenous injection, IV | bid | Tygacil | tigecycline | PDR |
| Max dose for children | 50.0 | mg/dose | 50 | mg/dose | intravenous injection, IV | bid | Tygacil | tigecycline | PDR |
| Max dose for adolescents | 50.0 | mg | 50 | mg | intravenous injection, IV | bid | Tygacil | tigecycline | PDR |
| Max dose for adults | 100.0 | mg/day | 100 | mg/day | intravenous injection, IV | Tygacil | tigecycline | PDR | |
| Max dose for geriatric | 100.0 | mg/day | 100 | mg/day | intravenous injection, IV | Tygacil | tigecycline | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1