Basic Information
| Drug ID | DDPD00558 |
|
| Drug Name | Zanamivir | |
| Molecular Weight | 332.3098 | |
| Molecular Formula | C12H20N4O7 | |
| CAS Number | 139110-80-8 | |
| SMILES | [H][C@]1(OC(=C[C@H](N=C(N)N)[C@H]1NC(C)=O)C(O)=O)[C@H](O)[C@H](O)CO | |
| External Links | ||
| DRUGBANK | DB00558 | |
| PubChem Compound | 60855 | |
| PDR | 219 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -3.0 | - | -3.0 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 2.0 | % | 2 | % | DRUGBANK | Bioavailability | 10.5 | % | 4-17 | % | inhalation, IH; | DRUGBANK |
| Metabolic | 0 | % | 0 | % | DRUGBANK | |
| Clearance | 6.7 | L/h | 2.5-10.9 | L/h | PO, oral; | DRUGBANK | Clearance | 5.3 | L/h | 5.3 | L/h | intravenous injection, IV; normal,healthy; | DRUGBANK | Clearance | 2.7 | L/h | 2.7 | L/h | intravenous injection, IV; mild renal function; moderate renal function; patients; | DRUGBANK | Clearance | 0.80 | L/h | 0.8 | L/h | intravenous injection, IV; severe renal function; patients; | DRUGBANK | Clearance | 0.0960 | L/h/kg | 1.6 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.23 | L/kg | 0.23 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 3.8 | h | 2.5-5.1 | h | DRUGBANK | Half-life | 1.7 | h | 1.7 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 10.0 | % | <10 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 4.0 | mg/kg/day | 8 | mg/kg/dose | intravenous injection, IV | q2d | Relenza | zanamivir | PDR |
| Max dose for infants | 7.0 | mg/kg/day | 14 | mg/kg/dose | intravenous injection, IV | q2d | Relenza | zanamivir | PDR |
| Max dose for infants | 6.0 | mg/kg/day | 12 | mg/kg/dose | intravenous injection, IV | q2d | Relenza | zanamivir | PDR |
| Max dose for infants | 5.0 | mg/kg/day | 10 | mg/kg/dose | intravenous injection, IV | q2d | Relenza | zanamivir | PDR |
| Max dose for children | 10.0 | mg | 10 | mg | inhalation, IH | q2d | Relenza | zanamivir | PDR |
| Max dose for children | 12.0 | mg/kg | 12 | mg/kg | intravenous injection, IV | q2d | Relenza | zanamivir | PDR |
| Max dose for children | 600.0 | mg/dose | 600 | mg/dose | intravenous injection, IV | q2d | Relenza | zanamivir | PDR |
| Max dose for children | 10.0 | mg | 10 | mg | inhalation, IH; for 5 days | q2d | Relenza | zanamivir | PDR |
| Max dose for children | 7.0 | mg/kg/day | 14 | mg/kg/dose | intravenous injection, IV | q2d | Relenza | zanamivir | PDR |
| Max dose for children | 7.0 | mg/kg/day | 14 | mg/kg/dose | intravenous injection, IV | q2d | Relenza | zanamivir | PDR |
| Max dose for adolescents | 10.0 | mg | 10 | mg | inhalation, IH | q2d | Relenza | zanamivir | PDR |
| Max dose for adolescents | 12.0 | mg/kg/dose | 12 | mg/kg/dose | intravenous injection, IV | q2d | Relenza | zanamivir | PDR |
| Max dose for adolescents | 600.0 | mg/dose | 600 | mg/dose | intravenous injection, IV | q2d | Relenza | zanamivir | PDR |
| Max dose for adults | 10.0 | mg | 10 | mg | inhalation, IH | q2d | Relenza | zanamivir | PDR |
| Max dose for adults | 600.0 | mg | 600 | mg | intravenous injection, IV | q2d | Relenza | zanamivir | PDR |
| Max dose for geriatric | 10.0 | mg | 10 | mg | inhalation, IH | q2d | Relenza | zanamivir | PDR |
| Max dose for geriatric | 600.0 | mg | 600 | mg | intravenous injection, IV | q2d | Relenza | zanamivir | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1