Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00557 ...
Drug Name Hydroxyzine
Molecular Weight 374.904
Molecular Formula C21H27ClN2O2
CAS Number 68-88-2
SMILES OCCOCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=C(Cl)C=C1
External Links
DRUGBANK DB00557
T3DB T3D2823
PubChem Compound 3658
PDR 3067
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 200.0 ℃ 200 ℃ Canadian Label

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
C Max 72.0 ng/ml 72±11 ng/ml PO, oral; Elderly; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 47.0 ng/ml 47±17 ng/ml PO, oral; Children; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 2.0 h 2 h PO, oral; DRUGBANK
T Max 2.1 h 2.1±0.4 h PO, oral; Elderly; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 2.0 h 2.0±0.9 h PO, oral; Children; normal,healthy; The Pharmacological Basis of Therapeutics
Metabolic 52.5 % 45-60 % PO, oral; DRUGBANK
Clearance 1.9 L/h/kg 31.1±11.1 ml/min/kg Children; DRUGBANK
Clearance 0.59 L/h/kg 9.8±3.3 ml/min/kg adults; DRUGBANK
Clearance 0.59 L/h/kg 9.8±3.3 ml/min/kg apparent clearance; PO, oral; The Pharmacological Basis of Therapeutics
Clearance 1.9 L/h/kg 32±11 ml/min/kg apparent clearance; PO, oral; The Pharmacological Basis of Therapeutics
Volume of Distribution 16.0 L/kg 16.0±3.0 L/kg Average volume of distribution; DRUGBANK
Volume of Distribution 16.0 L/kg 16±3 L/kg Apparent volume of distribution; PO, oral; The Pharmacological Basis of Therapeutics
Volume of Distribution 19.0 L/kg 19±9 L/kg Apparent volume of distribution; PO, oral; The Pharmacological Basis of Therapeutics
Half-life 20.0 h ~20(14-25) h adults; DRUGBANK
Half-life 7.1 h ~7.1 h Children; DRUGBANK
Half-life 29.0 h 29 h elimination half-life; Elderly; hepatopathy，LD ↑ ;RD, renal impairment, Renal disease，including uremia ↑ ; DRUGBANK
Half-life 20.0 h 20±4 h adults; PO, oral; chronic liver disease ↑ ;Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 7.1 h 7.1±2.3 h Children; PO, oral; chronic liver disease ↑ ;Age ↑ ; The Pharmacological Basis of Therapeutics
Toxicity LD50 840.0 mg/kg 840.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 400.0 mg/kg 400.0 mg/kg PO, oral; mouse; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 100.0 mg/day 100 mg/day PO, oral Vistaril hydroxyzine pamoate PDR
Max dose for children 2.0 mg/kg/day 2 mg/kg/day PO, oral Vistaril hydroxyzine pamoate PDR
Max dose for children 1.1 mg/kg/dose 1.1 mg/kg/dose IM,intramuscular injection Vistaril hydroxyzine pamoate PDR
Max dose for children 50.0 mg/day 50 mg/day PO, oral Vistaril hydroxyzine pamoate PDR
Max dose for children 2.0 mg/kg/day 2 mg/kg/day PO, oral Vistaril hydroxyzine pamoate PDR
Max dose for children 1.1 mg/kg/dose 1.1 mg/kg/dose IM,intramuscular injection Vistaril hydroxyzine pamoate PDR
Max dose for adolescents 100.0 mg/day 100 mg/day PO, oral Vistaril hydroxyzine pamoate PDR
Max dose for adolescents 2.0 mg/kg/day 2 mg/kg/day PO, oral Vistaril hydroxyzine pamoate PDR
Max dose for adolescents 1.1 mg/kg/dose 1.1 mg/kg/dose IM,intramuscular injection Vistaril hydroxyzine pamoate PDR
Max dose for adults 400.0 mg/day 400 mg/day PO, oral Vistaril hydroxyzine pamoate PDR
Max dose for adults 600.0 mg/day 600 mg/day IM,intramuscular injection Vistaril hydroxyzine pamoate PDR
Max dose for geriatric 400.0 mg/day 400 mg/day PO, oral Vistaril hydroxyzine pamoate PDR
Max dose for geriatric 600.0 mg/day 600 mg/day IM,intramuscular injection Vistaril hydroxyzine pamoate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1