Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00555 ...
Drug Name Lamotrigine
Molecular Weight 256.091
Molecular Formula C9H7Cl2N5
CAS Number 84057-84-1
SMILES NC1=NC(N)=C(N=N1)C1=C(Cl)C(Cl)=CC=C1
External Links
DRUGBANK DB00555
T3DB T3D2570
PubChem Compound 3878
PDR 206
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.93 - 1.93 - http://www.t3db.ca/toxins/T3D2570
Boiling Point 503.1 ℃ 503.1±60.0 ℃ https://www.chemicalbook.com/ChemicalProductProperty_US_CB4166704.aspx
Melting Point 179.0 ℃ 177-181 ℃ https://www.chemicalbook.com/ChemicalProductProperty_US_CB4166704.aspx
Water Solubility 170.0 mg/L 0.17 mg/ml FDA label
pKa 5.7 - 5.7 - FDA label

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 98.0 % ~98 % DRUGBANK
Bioavailability 97.6 % 97.6±4.8 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 2500.0 ng/ml 2.5±0.4 mcg/ml Oral single dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 3.1 h 1.4-4.8 h DRUGBANK
T Max 2.2 h 2.2±1.2 h Oral single dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Metabolic 10.0 % 10 % Urinary excretion; Unchanged drug; DRUGBANK
Metabolic 76.0 % 76 % DRUGBANK
Metabolic 10.0 % 10 % DRUGBANK
Metabolic 14.0 % 14 % DRUGBANK
Clearance 0.0417 L/h/kg 0.18-1.21 ml/min/kg Plasma clearance; DRUGBANK
Clearance 0.0264 L/h/kg 0.44 ml/min/kg normal,healthy; DRUGBANK
Clearance 0.0297 L/h/kg 0.38-0.61 ml/min/kg hepatopathy，LD ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.1 L/kg 0.9-1.3 L/kg Apparent volume of distribution; PO, oral; DRUGBANK
Volume of Distribution 1.0 L/kg 0.87-1.2 L/kg The Pharmacological Basis of Therapeutics
Half-life 36.5 h 14-59 h elimination half-life; DRUGBANK
Half-life 29.5 h 24-35 h moderate hepatic impairment ↑ ;severe hepatic impairment ↑ ;severe renal function ↑ ;enzyme-inducers ↓ ; The Pharmacological Basis of Therapeutics
Toxicity LD50 205.0 mg/kg 205.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 245.0 mg/kg 245.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 250.0 mg/kg 250.0 mg/kg mouse; T3DB
Toxicity LD50 250.0 mg/kg 250.0 mg/kg Rattus, Rat; T3DB
Toxicity LD50 640.0 mg/kg >640 mg/kg PO, oral; Rattus, Rat; T3DB
Toxicity LD50 640.0 mg/kg >640 mg/kg PO, oral; mouse; T3DB
Eliminate Route 94.0 % ~94 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 2.0 % ~2 % Faeces excretion; PO, oral; DRUGBANK
Eliminate Route 10.0 % 10 % Urinary excretion; adults; normal,healthy; epilepsy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 55.0 % 55 % plasma proteins; DRUGBANK
Protein Binding 56.0 % 56 % adults; normal,healthy; epilepsy; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 200.0 mg/day 200 mg/day PO, oral Lamictal lamotrigine PDR
Max dose for children 400.0 mg/day 400 mg/day PO, oral Lamictal lamotrigine PDR
Max dose for children 300.0 mg/day 300 mg/day PO, oral Lamictal lamotrigine PDR
Max dose for adults 200.0 mg/day 200 mg/day PO, oral Lamictal lamotrigine PDR
Max dose for adults 100.0 mg/day 100 mg/day PO, oral Lamictal lamotrigine PDR
Max dose for adults 400.0 mg/day 400 mg/day PO, oral Lamictal lamotrigine PDR
Max dose for elderly 200.0 mg/day 200 mg/day PO, oral Lamictal lamotrigine PDR
Max dose for elderly 100.0 mg/day 100 mg/day PO, oral Lamictal lamotrigine PDR
Max dose for elderly 400.0 mg/day 400 mg/day PO, oral Lamictal lamotrigine PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1