Basic Information
| Drug ID | DDPD00554 |
|
| Drug Name | Piroxicam | |
| Molecular Weight | 331.346 | |
| Molecular Formula | C15H13N3O4S | |
| CAS Number | 36322-90-4 | |
| SMILES | CN1C(C(=O)NC2=NC=CC=C2)=C(O)C2=C(C=CC=C2)S1(=O)=O | |
| External Links | ||
| DRUGBANK | DB00554 | |
| PubChem Compound | 54676228 | |
| PDR | 1000 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Caco-2 Permeability | -4.45 | - | -4.45 | - | ADME Research, USCD |
| Log P | 3.06 | - | 3.06 | - | AVDEEF,A (1997) |
| Melting Point | 199.0 | ℃ | 198-200 | ℃ | PhysProp |
| Water Solubility | 23.0 | mg/L | 23 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| pKa | 6.3 | - | 6.3 | - | SANGSTER (1994) |
| Log S | -4.16 | - | -4.16 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Volume of Distribution | 0.14 | L/kg | 0.14 | L/kg | DRUGBANK | |
| Half-life | 58.0 | h | 30-86 | h | DRUGBANK | |
| Eliminate Route | 5.0 | % | ~5 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 20.0 | mg/day | 20 | mg/day | PO, oral | Feldene | piroxicam | PDR |
| Max dose for elderly | 20.0 | mg/day | 20 | mg/day | PO, oral | Feldene | piroxicam | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1