Basic Information
| Drug ID | DDPD00552 |
|
| Drug Name | Pentostatin | |
| Molecular Weight | 268.2691 | |
| Molecular Formula | C11H16N4O4 | |
| CAS Number | 53910-25-1 | |
| SMILES | OC[C@H]1O[C@H](C[C@@H]1O)N1C=NC2=C1N=CNC[C@H]2O | |
| External Links | ||
| DRUGBANK | DB00552 | |
| T3DB | T3D2822 | |
| PubChem Compound | 439693 | |
| PDR | 2557 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -1.1 | - | -1.1 | - | DRUGBANK |
| Melting Point | 220.0 | ℃ | 220 | ℃ | PhysProp |
| Water Solubility | 30000.0 | mg/L | 30 | mg/ml | DRUGBANK |
| pKa | 5.2 | - | 5.2 | - | MERCK INDEX (1996) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 0 | % | 0 | % | PO, oral; | DRUGBANK |
| Clearance | 4.1 | L/h/m2 | 68.0 | ml/min/m2 | DRUGBANK | Clearance | 0.0978 | L/h/kg | 1.63 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.59 | L/kg | 0.59 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 5.7 | h | 5.7(2.6-16 | h | DRUGBANK | Half-life | 5.3 | h | 5.3 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 128.0 | mg/kg | 128.0 | mg/kg | mouse; | DRUGBANK | Toxicity LD50 | 128.0 | mg/kg | 128.0 | mg/kg | mouse; | T3DB |
| Eliminate Route | 90.0 | % | ~90 | % | Urinary excretion; human, homo sapiens; | DRUGBANK |
| Protein Binding | 4.0 | % | 4 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 4.0 | mg/m2 | 4 | mg/m2 | intravenous injection, IV | qow | Nipent | pentostatin | PDR |
| Max dose for geriatric | 4.0 | mg/m2 | 4 | mg/m2 | intravenous injection, IV | qow | Nipent | pentostatin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1