Basic Information
| Drug ID | DDPD00550 |
|
| Drug Name | Propylthiouracil | |
| Molecular Weight | 170.232 | |
| Molecular Formula | C7H10N2OS | |
| CAS Number | 51-52-5 | |
| SMILES | CCCC1=CC(=O)NC(=S)N1 | |
| External Links | ||
| DRUGBANK | DB00550 | |
| T3DB | T3D4712 | |
| PubChem Compound | 657298 | |
| PDR | 787 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.4 | - | 0.4 | - | DRUGBANK |
| Melting Point | 219.0 | ℃ | 219 | ℃ | PhysProp |
| Water Solubility | 1200.0 | mg/L | 1200 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| Log S | -2.15 | - | -2.15 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 0.19 | L/h/kg | 3.1 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.34 | L/kg | 0.34 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 2.0 | h | 2 | h | DRUGBANK | Half-life | 1.3 | h | 1.3 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 1250.0 | mg/kg | 1250.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 1250.0 | mg/kg | 1250.0 | mg/kg | PO, oral; Rattus, Rat; | T3DB |
| Eliminate Route | 35.0 | % | ~35 | % | Urinary excretion; | DRUGBANK |
| Protein Binding | 82.0 | % | 82 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for infants | 300.0 | mg/day | 300 | mg/day | PO, oral | Propylthiouracil | propylthiouracil | PDR |
| Max dose for infants | 7.0 | mg/kg/day | 7 | mg/kg/day | PO, oral | Propylthiouracil | propylthiouracil | PDR |
| Max dose for infants | 150.0 | mg/day | 150 | mg/day | PO, oral | Propylthiouracil | propylthiouracil | PDR |
| Max dose for infants | 7.0 | mg/kg/day | 7 | mg/kg/day | PO, oral | Propylthiouracil | propylthiouracil | PDR |
| Max dose for children | 300.0 | mg/day | 300 | mg/day | PO, oral | Propylthiouracil | propylthiouracil | PDR |
| Max dose for children | 7.0 | mg/kg/day | 7 | mg/kg/day | PO, oral | Propylthiouracil | propylthiouracil | PDR |
| Max dose for adolescents | 900.0 | mg/day | 900 | mg/day | PO, oral | Propylthiouracil | propylthiouracil | PDR |
| Max dose for adolescents | 1200.0 | mg/day | 1.2 | g/day | PO, oral | Propylthiouracil | propylthiouracil | PDR |
| Max dose for geriatric | 900.0 | mg/day | 900 | mg/day | PO, oral | Propylthiouracil | propylthiouracil | PDR |
| Max dose for geriatric | 1200.0 | mg/day | 1.2 | g/day | PO, oral | Propylthiouracil | propylthiouracil | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1