Basic Information
| Drug ID | DDPD00545 |
|
| Drug Name | Pyridostigmine | |
| Molecular Weight | 181.2117 | |
| Molecular Formula | C9H13N2O2 | |
| CAS Number | 155-97-5 | |
| SMILES | CN(C)C(=O)OC1=C[N+](C)=CC=C1 | |
| External Links | ||
| DRUGBANK | DB00545 | |
| T3DB | T3D2820 | |
| PubChem Compound | 4991 | |
| PDR | 1218 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.554 | - | 1.554 | - | DRUGBANK |
| Melting Point | 153.0 | ℃ | 153 | ℃ | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 7.6 | % | 7.6±2.4 | % | DRUGBANK | |
| Clearance | 0.58 | L/h/kg | 9.6 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.1 | L/kg | 1.1 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 3.0 | h | 3 | h | PO, oral; | DRUGBANK | Half-life | 1.5 | h | 1.5 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 1.0 | mg/kg/dose | 1 | mg/kg/dose | PO, oral | Regonol | pyridostigmine bromide | PDR |
| Max dose for neonates | 7.0 | mg/kg/day | 7 | mg/kg/day | PO, oral | Regonol | pyridostigmine bromide | PDR |
| Max dose for infants | 1.0 | mg/kg/dose | 1 | mg/kg/dose | PO, oral | Regonol | pyridostigmine bromide | PDR |
| Max dose for infants | 7.0 | mg/kg/day | 7 | mg/kg/day | PO, oral | Regonol | pyridostigmine bromide | PDR |
| Max dose for children | 60.0 | mg/dose | 60 | mg/dose | PO, oral | Regonol | pyridostigmine bromide | PDR |
| Max dose for children | 1.0 | mg/kg/dose | 1 | mg/kg/dose | PO, oral | Regonol | pyridostigmine bromide | PDR |
| Max dose for children | 300.0 | mg/day | 300 | mg/day | PO, oral | Regonol | pyridostigmine bromide | PDR |
| Max dose for children | 7.0 | mg/kg/day | 7 | mg/kg/day | PO, oral | Regonol | pyridostigmine bromide | PDR |
| Max dose for adolescents | 60.0 | mg/dose | 60 | mg/dose | PO, oral | Regonol | pyridostigmine bromide | PDR |
| Max dose for adolescents | 1.0 | mg/kg/dose | 1 | mg/kg/dose | PO, oral | Regonol | pyridostigmine bromide | PDR |
| Max dose for adolescents | 300.0 | mg/day | 300 | mg/day | PO, oral | Regonol | pyridostigmine bromide | PDR |
| Max dose for adolescents | 7.0 | mg/kg/day | 7 | mg/kg/day | PO, oral | Regonol | pyridostigmine bromide | PDR |
| Max dose for adults | 1500.0 | mg/day | 1500 | mg/day | PO, oral | Regonol | pyridostigmine bromide | PDR |
| Max dose for adults | 1080.0 | mg/day | 1080 | mg/day | PO, oral | Regonol | pyridostigmine bromide | PDR |
| Max dose for adults | 180.0 | mg/day | 180 | mg/day | PO, oral | Regonol | pyridostigmine bromide | PDR |
| Max dose for adults | 0.25 | mg/kg/dose | 0.25 | mg/kg/dose | intravenous injection, IV; on days 1, 3, and 5 | Regonol | pyridostigmine bromide | PDR |
| Max dose for geriatric | 1500.0 | mg/day | 1500 | mg/day | PO, oral | Regonol | pyridostigmine bromide | PDR |
| Max dose for geriatric | 1080.0 | mg/day | 1080 | mg/day | Tablet,PO，oral | Regonol | pyridostigmine bromide | PDR |
| Max dose for geriatric | 180.0 | mg/day | 180 | mg/day | PO, oral | Regonol | pyridostigmine bromide | PDR |
| Max dose for geriatric | 0.25 | mg/kg/dose | 0.25 | mg/kg/dose | intravenous injection, IV | Regonol | pyridostigmine bromide | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1