Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00544 ...
Drug Name Fluorouracil
Molecular Weight 130.0772
Molecular Formula C4H3FN2O2
CAS Number 51-21-8
SMILES FC1=CNC(=O)NC1=O
External Links
DRUGBANK DB00544
T3DB T3D4776
PubChem Compound 3385
PDR 1112
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -0.89 - -0.89 - HANSCH,C ET AL. (1995)
Melting Point 282.5 ℃ 282-283 ℃ Heidelberger, C. and Duschinsky, R.; US. Patent 2,802,005; August 6, 1957. Heidelberger, C. and Duschinsky, R.; U.S.Patent 2,885,396; May 5, 1959.
Water Solubility 11100.0 mg/L 11100 mg/L BURR,A & BUNDGAARD,H 1985)
pKa 8.02 - 8.02 - SANGSTER (1994)
Log S -1.07 - -1.07 - ADME Research, USCD

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Absorption 64.0 % 28-100 % DRUGBANK
Bioavailability 28.0 % 28(0-80) % PO, oral; The Pharmacological Basis of Therapeutics
C Max 1456864.6 ng/ml 11.2 mM intravenous infusion, IV in drop; tumor; The Pharmacological Basis of Therapeutics
Clearance 0.96 L/h/kg 16±7 ml/min/kg The Pharmacological Basis of Therapeutics
Clearance 1.6 L/h/kg 26 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.25 L/kg 0.25±0.12 L/kg The Pharmacological Basis of Therapeutics
Volume of Distribution 0.23 L/kg 0.23 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 0.25 h 10-20 min DRUGBANK
Half-life 0.18 h 11±4 min The Pharmacological Basis of Therapeutics
Half-life 20.0 h ~20 h terminal half-life; The Pharmacological Basis of Therapeutics
Half-life 0.12 h 0.12 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 230.0 mg/kg 230.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 230.0 mg/kg 230.0 mg/kg PO, oral; mouse; T3DB
Eliminate Route 13.5 % 7-20 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 10.0 % <10 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 10.0 % 8-12 % DRUGBANK
Protein Binding 10.0 % 8-12 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adolescents 800.0 mg/day 800 mg/day intravenous injection, IV Fluoroplex fluorouracil PDR
Max dose for adolescents 22.5 mg/kg 22.5 mg/kg Fluoroplex fluorouracil PDR
Max dose for geriatric 800.0 mg/day 800 mg/day intravenous injection, IV Fluoroplex fluorouracil PDR
Max dose for geriatric 22.5 mg/kg 22.5 mg/kg Fluoroplex fluorouracil PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1