Property Name |
Property Value |
Unit |
Raw Value |
Raw Unit |
Annotation |
Factor |
Reference |
C Max |
278.4 |
ng/ml |
~250-425 |
nM |
intravenous injection, IV; |
|
The Pharmacological Basis of Therapeutics |
Clearance |
4.9 |
L/h/m2 |
4.92±3.01 |
L/h/m2 |
tumor; patients; Male, men; Female, women; Bile excretion; hydrolysis; |
Children → ;hepatopathy,LD ↓ ; |
The Pharmacological Basis of Therapeutics |
Clearance |
0.12 |
L/h/kg |
2 |
ml/min/kg |
intravenous injection, IV; human, homo sapiens; |
|
Human Intravenous Pharmacokinetic Dataset |
Volume of Distribution |
96.6 |
L/m2 |
96.6±55.7 |
L/m2 |
tumor; patients; Male, men; Female, women; Bile excretion; hydrolysis; |
|
The Pharmacological Basis of Therapeutics |
Volume of Distribution |
2.4 |
L/kg |
2.4 |
L/kg |
intravenous injection, IV; human, homo sapiens; |
|
Human Intravenous Pharmacokinetic Dataset |
Half-life |
0.0833 |
h |
5 |
min |
distribution half-life; intravenous injection, IV; tumor; patients; |
|
DRUGBANK |
Half-life |
2.3 |
h |
2.3 |
h |
elimination half-life; intravenous injection, IV; tumor; patients; |
|
DRUGBANK |
Half-life |
85.0 |
h |
85 |
h |
terminal half-life; intravenous injection, IV; tumor; patients; |
|
DRUGBANK |
Half-life |
87.0 |
h |
19-155 |
h |
terminal half-life; human, homo sapiens; |
|
DRUGBANK |
Half-life |
22.6 |
h |
22.6±16.7 |
h |
|
chronic liver disease ↑ ; |
The Pharmacological Basis of Therapeutics |
Half-life |
85.0 |
h |
~85±69 |
h |
|
|
The Pharmacological Basis of Therapeutics |
Half-life |
23.0 |
h |
23 |
h |
intravenous injection, IV; human, homo sapiens; |
|
Human Intravenous Pharmacokinetic Dataset |
Toxicity LD50 |
1300.0 |
mg/kg |
1300.0 |
mg/kg |
intravenous injection, IV; Rattus, Rat; |
|
DRUGBANK |
Toxicity LD50 |
5.2 |
mg/kg |
5.2 |
mg/kg |
Intraperitoneal, IP; mouse; |
|
DRUGBANK |
Toxicity LD50 |
1300.0 |
mg/kg |
1300.0 |
mg/kg |
intravenous injection, IV; Rattus, Rat; |
|
T3DB |
Toxicity LD50 |
5.2 |
mg/kg |
5.2 |
mg/kg |
Intraperitoneal, IP; mouse; |
|
T3DB |
Eliminate Route |
80.0 |
% |
80 |
% |
Faeces excretion; |
|
DRUGBANK |
Eliminate Route |
15.0 |
% |
10-20 |
% |
Urinary excretion; |
|
DRUGBANK |
Eliminate Route |
15.0 |
% |
10-20 |
% |
Urinary excretion; adults; tumor; human, homo sapiens; Unchanged drug; |
|
The Pharmacological Basis of Therapeutics |
Protein Binding |
75.0 |
% |
~75 |
% |
|
|
DRUGBANK |