DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD00538
Drug Name	Gadoversetamide
Molecular Weight	661.76
Molecular Formula	C20H34GdN5O10
CAS Number	131069-91-5
SMILES	[Gd+3].COCCNC(=O)CN(CCN(CCN(CC([O-])=O)CC(=O)NCCOC)CC([O-])=O)CC([O-])=O
External Links
	DRUGBANK	DB00538
	PubChem Compound	444013
	PDR	1390

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Reference
Clearance	0.0720	L/h/kg	72±16.3	ml/h/kg	normal,healthy;	DRUGBANK
Clearance	0.0720	L/h/kg	1.2	ml/min/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Volume of Distribution	0.16	L/kg	162±25	ml/kg	normal,healthy;	DRUGBANK
Volume of Distribution	0.16	L/kg	0.16	L/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Half-life	0.22	h	13.3±6.8	min	distribution half-life;	DRUGBANK
Half-life	1.7	h	103.6±19.5	min	elimination half-life;	DRUGBANK
Half-life	1.7	h	1.7	h	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Eliminate Route	93.5	%	~93.5	%	Urinary excretion; RD, renal impairment, Renal disease，including uremia;	DRUGBANK
Eliminate Route	95.8	%	~95.8	%	Urinary excretion; patients;	DRUGBANK

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for adults	0.2	ml/kg/dose	0.2	ml/kg/dose	intravenous injection, IV	Optimark	gadoversetamide	PDR
Max dose for adults	0.1	mmoL/kg/dose	0.1	mmoL/kg/dose	intravenous injection, IV	Optimark	gadoversetamide	PDR
Max dose for geriatric	0.2	ml/kg/dose	0.2	ml/kg/dose	intravenous injection, IV	Optimark	gadoversetamide	PDR
Max dose for geriatric	0.1	mmol/kg/dose	0.1	mmol/kg/dose	intravenous injection, IV	Optimark	gadoversetamide	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1