Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00537 ...
Drug Name Ciprofloxacin
Molecular Weight 331.3415
Molecular Formula C17H18FN3O3
CAS Number 85721-33-1
SMILES OC(=O)C1=CN(C2CC2)C2=CC(N3CCNCC3)=C(F)C=C2C1=O
External Links
DRUGBANK DB00537
T3DB T3D3495
PubChem Compound 2764
PDR 1086
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 0.28 - 0.28 - TAKACS-NOVAK,K ET AL. (1992)
Melting Point 256.0 ℃ 255-257 ℃ http://www.chemspider.com/Chemical-Structure.2662.html
Water Solubility 1000.0 mg/L <1 mg/ml http://www.chemspider.com/Chemical-Structure.2662.html
pKa 6.09 - 6.09 - TORNIANEN,K ET AL. (1996)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 1013000000.0 ng.h/ml 1.013 kg.h/L DRUGBANK
Bioavailability 75.0 % 70-80 % PO, oral; DRUGBANK
Bioavailability 70.0 % 70 % PO, oral; different study; DRUGBANK
Bioavailability 60.0 % 60±12 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 940.0 ng/ml 0.94 mg/L DRUGBANK
C Max 2500.0 ng/ml 2.5±1.1 mcg/ml PO, oral; chronic bronchitis; The Pharmacological Basis of Therapeutics
T Max 0.81 h 0.81 h DRUGBANK
T Max 0.60 h 0.6±0.2 h PO, oral; chronic bronchitis; The Pharmacological Basis of Therapeutics
Metabolic 5.5 % 3-8 % DRUGBANK
Clearance 0.30 L/h/kg 5.08 ml/min/kg Renal clearance; PO, oral; DRUGBANK
Clearance 0.58 L/h/kg 9.62 ml/min/kg Average clearance; intravenous injection, IV; DRUGBANK
Clearance 0.27 L/h/kg 4.42 ml/min/kg Renal clearance; intravenous injection, IV; DRUGBANK
Clearance 0.31 L/h/kg 5.21 ml/min/kg Plasma clearance; intravenous injection, IV; DRUGBANK
Clearance 0.46 L/h/kg 7.6±0.8 ml/min/kg Elderly ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ;Cystic fibrosis ↑ ; The Pharmacological Basis of Therapeutics
Clearance 0.50 L/h/kg 8.3 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.16 L/kg 0.161 L/kg DRUGBANK
Volume of Distribution 2.5 L/kg 2.00-3.04 L/kg Total volume of distribution; DRUGBANK
Volume of Distribution 2.2 L/kg 2.2±0.4 L/kg Elderly ↓ ;Cystic fibrosis → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 2.1 L/kg 2.1 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 4.7 h 4.71 h PO, oral; DRUGBANK
Half-life 3.7 h 3.65 h intravenous injection, IV; DRUGBANK
Half-life 4.0 h 4 h DRUGBANK
Half-life 3.3 h 3.3±0.4 h RD, renal impairment, Renal disease，including uremia ↑ ;Cystic fibrosis ↓ ;Age → ; The Pharmacological Basis of Therapeutics
Half-life 3.8 h 3.8 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 2000.0 mg/kg >2000 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 45.0 % 45 % Urinary excretion; DRUGBANK
Eliminate Route 62.0 % 62 % Faeces excretion; DRUGBANK
Eliminate Route 50.0 % 50±5 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 30.0 % 20-40 % DRUGBANK
Protein Binding 40.0 % 40 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 45.0 mg/kg/day 45 mg/kg/day PO, oral Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for neonates 30.0 mg/kg/day 30 mg/kg/day intravenous injection, IV Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for neonates 120.0 drop/day 120 drop/day ophthalmic administration Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for infants 45.0 mg/kg/day 45 mg/kg/day PO, oral Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for infants 30.0 mg/kg/day 30 mg/kg/day intravenous injection, IV Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for infants 120.0 drop/day 120 drop/day ophthalmic administration Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for infants 12.0 mg/ear 12 mg/ear intraaural administration Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for infants 45.0 mg/kg/day 45 mg/kg/day PO, oral Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for infants 30.0 mg/kg/day 30 mg/kg/day intravenous injection, IV Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for infants 120.0 drop/day 120 drop/day ophthalmic administration Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for children 45.0 mg/kg/day 45 mg/kg/day PO, oral Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for children 1500.0 mg/day 1.5 g/day PO, oral Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for children 30.0 mg/kg/day 30 mg/kg/day intravenous injection, IV Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for children 1200.0 mg/day 1.2 g/day intravenous injection, IV Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for children 2000.0 mg/day 2 g/day PO, oral Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for children 1.0 mg/ear/day 1 mg/ear/day intraaural administration Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for children 12.0 mg/ear 12 mg/ear intraaural administration Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for children 120.0 drop/day 120 drop/day ophthalmic administration Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for children 45.0 mg/kg/day 45 mg/kg/day PO, oral Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for children 30.0 mg/kg/day 30 mg/kg/day intravenous injection, IV Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for children 1.0 mg/ear/day 1 mg/ear/day intraaural administration Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for children 12.0 mg/ear 12 mg/ear intraaural administration Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for children 120.0 drop/day 120 drop/day ophthalmic administration Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for adolescents 45.0 mg/kg/day 45 mg/kg/day PO, oral Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for adolescents 1500.0 mg/day 1.5 g/day PO, oral Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for adolescents 30.0 mg/kg/day 30 mg/kg/day intravenous injection, IV Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for adolescents 1200.0 mg/day 1.2 g/day intravenous injection, IV Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for adolescents 2000.0 mg/day 2 g/day PO, oral Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for adolescents 1.0 mg/day 1 mg/ear/day intraaural administration Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for adolescents 12.0 mg 12 mg/ear intraaural administration Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for adolescents 120.0 drop/day 120 drop/day ophthalmic administration Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for adults 1500.0 mg/day 1.5 g/day PO, oral Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for adults 1000.0 mg/day 1 g/day PO, oral Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for adults 1200.0 mg/day 1.2 g/day intravenous injection, IV Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for adults 1.0 mg/ear/day 1 mg/ear/day intraaural administration Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for adults 12.0 mg/ear 12 mg/ear intraaural administration Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for adults 120.0 drop/day 120 drop/day ophthalmic administration Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for geriatric 1500.0 mg/day 1.5 g/day PO, oral Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for geriatric 1000.0 mg/day 1 g/day PO, oral Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for geriatric 1200.0 mg/day 1.2 g/day intravenous injection, IV Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for geriatric 1.0 mg/ear/day 1 mg/ear/day intraaural administration Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for geriatric 12.0 mg/ear 12 mg/ear intraaural administration Ciloxan Ointment ciprofloxacin hydrochloride PDR
Max dose for geriatric 120.0 drop/day 120 drop/day ophthalmic administration Ciloxan Ointment ciprofloxacin hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1