Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00535 ...
Drug Name Cefdinir
Molecular Weight 395.414
Molecular Formula C14H13N5O5S2
CAS Number 91832-40-5
SMILES [H][C@]12SCC(C=C)=C(N1C(=O)[C@H]2NC(=O)C(=N/O)\C1=CSC(N)=N1)C(O)=O
External Links
DRUGBANK DB00535
PubChem Compound 6915944
PDR 1661
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -3.47 - -3.47 - https://aac.asm.org/content/47/2/689
Boiling Point 708.82 ℃ 708.82 ℃ https://cymitquimica.com/products/45-1097614/213978-34-8/cefdinir/
Melting Point 135.0 ℃ >135 ℃ https://www.trc-canada.com/product-detail/?CatNum=C242670
Water Solubility 8.85 mg/L 8.85±0.87 mg/ml https://www.mdpi.com/1420-3049/22/2/280/htm
pKa 9.7 - 9.7 - https://www.chemicalbook.com/ChemicalProductProperty_US_CB7483101.aspx

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 7050.0 ng.h/ml 7.05 ug.h/ml PO, oral; DRUGBANK
AUC 11000.0 ng.h/ml 11.0 ug.h/ml PO, oral; DRUGBANK
Bioavailability 18.5 % 16-21 % Capsule, PO, Oral; DRUGBANK
Bioavailability 25.0 % 25 % Liquid; DRUGBANK
Bioavailability 18.5 % 16-21 % Capsule, PO, Oral; The Pharmacological Basis of Therapeutics
Bioavailability 25.0 % 25.0 % Liquid; The Pharmacological Basis of Therapeutics
C Max 1600.0 ng/ml 1.6 ug/ml PO, oral; DRUGBANK
C Max 2870.0 ng/ml 2.87 ug/ml PO, oral; DRUGBANK
C Max 2900.0 ng/ml 2.9±1.0 mcg/ml Capsule, PO, Oral; adults; The Pharmacological Basis of Therapeutics
C Max 3900.0 ng/ml 3.9±0.6 mcg/ml Capsule, PO, Oral; Children; The Pharmacological Basis of Therapeutics
T Max 3.0 h 2-4 h DRUGBANK
T Max 3.0 h 3±0.7 h Capsule, PO, Oral; adults; The Pharmacological Basis of Therapeutics
T Max 2.0 h 2±0.4 h Capsule, PO, Oral; Children; The Pharmacological Basis of Therapeutics
Clearance 0.12 L/h/kg 2.0±1.0 ml/min/kg Renal clearance; normal,healthy; adults; RD, renal impairment, Renal disease，including uremia ↓ ; DRUGBANK
Clearance 0.78 L/h/kg 11-15 ml/min/kg apparent clearance; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.35 L/kg 0.35 L/kg Average volume of distribution; adults; DRUGBANK
Volume of Distribution 0.67 L/kg 0.67 L/kg Average volume of distribution; Children; DRUGBANK
Volume of Distribution 1.8 L/kg 1.56-2.09 L/kg adults; DRUGBANK
Volume of Distribution 1.9 L/kg 1.6-2.1 L/kg Steady state volume of distribution; The Pharmacological Basis of Therapeutics
Half-life 1.7 h ~1.7 h elimination half-life; adults; DRUGBANK
Half-life 1.4 h 1.2-1.5 h elimination half-life; Children; normal,healthy; Infants; DRUGBANK
Half-life 1.5 h 1.4-1.5 h The Pharmacological Basis of Therapeutics
Toxicity LD50 2000.0 mg/kg >2000 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 18.4 % ~18.4 % Urinary excretion; Unchanged drug; renal insufficiency → ; DRUGBANK
Eliminate Route 18.0 % 13-23 % Urinary excretion; Oral single dose; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 65.0 % ~60-70 % plasma proteins; DRUGBANK
Protein Binding 89.0 % 89 % RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Protein Binding 72.5 % 71-74 % peritoneal dialysis; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for infants 14.0 mg/kg/day 14 mg/kg/day PO, oral Cefdinir Capsules cefdinir PDR
Max dose for infants 14.0 mg/kg/day 14 mg/kg/day PO, oral Cefdinir Capsules cefdinir PDR
Max dose for children 14.0 mg/kg/day 14 mg/kg/day PO, oral Cefdinir Capsules cefdinir PDR
Max dose for children 600.0 mg/day 600 mg/day PO, oral Cefdinir Capsules cefdinir PDR
Max dose for adolescents 600.0 mg/day 600 mg/day PO, oral Cefdinir Capsules cefdinir PDR
Max dose for adults 600.0 mg/day 600 mg/day PO, oral Cefdinir Capsules cefdinir PDR
Max dose for geriatric 600.0 mg/day 600 mg/day PO, oral Cefdinir Capsules cefdinir PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1