Basic Information

Drug ID DDPD00533 ...
Drug Name Rofecoxib
Molecular Weight 314.356
Molecular Formula C17H14O4S
CAS Number 162011-90-7
SMILES CS(=O)(=O)C1=CC=C(C=C1)C1=C(C(=O)OC1)C1=CC=CC=C1
External Links
DRUGBANK DB00533
PubChem Compound 5090
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.2 - 3.2 - DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 93.0 % 93 % PO, oral; DRUGBANK
Bioavailability 93.0 % 93 % PO, oral; DRUGBANK
Bioavailability 93.0 % 93 % PO, oral; DRUGBANK
Metabolic 64.8 % 64.8 % Urinary excretion; DRUGBANK
Clearance 0.12 L/h/kg 2 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 1.3 L/kg 1.3 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 17.0 h 17 h DRUGBANK
Half-life 7.5 h 7.5 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Protein Binding 87.0 % 87 % DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1