Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00529 ...
Drug Name Foscarnet
Molecular Weight 126.0053
Molecular Formula CH3O5P
CAS Number 4428-95-9
SMILES OC(=O)P(O)(O)=O
External Links
DRUGBANK DB00529
PubChem Compound 3415
PDR 3639
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -2.1 - -2.1 - DRUGBANK
Melting Point 88.06 ℃ 88.06 ℃ DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 17.0 % 12-22 % PO, oral; DRUGBANK
Bioavailability 9.0 % 9±2 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 10836455.8 ng/ml 86±36 mM PO, oral; severe renal function; AIDS,HIV; The Pharmacological Basis of Therapeutics
T Max 1.4 h 1.4±0.6 h PO, oral; severe renal function; AIDS,HIV; The Pharmacological Basis of Therapeutics
Metabolic 0 % 0 % DRUGBANK
Clearance 0.13 L/h/kg 2.13±0.71 ml/min/kg normal,healthy; patients; DRUGBANK
Clearance 4.1 L/h/kg 68±8 ml/min/kg mild renal function; DRUGBANK
Clearance 2.0 L/h/kg 34±9 ml/min/kg moderate renal function; DRUGBANK
Clearance 1.2 L/h/kg 20±4 ml/min/kg severe renal function; DRUGBANK
Clearance 0.0984 L/h/kg 1.6±0.2 ml/min/kg moderate renal function ↓ ;severe renal function ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.13 L/h/kg 2.1 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.35 L/kg 0.35 L/kg The Pharmacological Basis of Therapeutics
Volume of Distribution 0.50 L/kg 0.5 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 5.1 h 3.3-6.8 h DRUGBANK
Half-life 5.7 h 5.7±0.2 h moderate renal function; severe renal function; The Pharmacological Basis of Therapeutics
Half-life 4.7 h 4.7 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 2000.0 mg/kg >2000 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 95.0 % 95±5 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 15.5 % 14-17 % DRUGBANK
Protein Binding 15.5 % 14-17 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for infants 180.0 mg/kg/day 180 mg/kg/day intravenous injection, IV Foscavir foscarnet sodium PDR
Max dose for children 180.0 mg/kg/day 180 mg/kg/day intravenous injection, IV Foscavir foscarnet sodium PDR
Max dose for adolescents 180.0 mg/kg/day 180 mg/kg/day intravenous injection, IV Foscavir foscarnet sodium PDR
Max dose for adults 180.0 mg/kg/day 180 mg/kg/day intravenous injection, IV Foscavir foscarnet sodium PDR
Max dose for geriatric 180.0 mg/kg/day 180 mg/kg/day intravenous injection, IV Foscavir foscarnet sodium PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1