Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00526 ...
Drug Name Oxaliplatin
Molecular Weight 397.294
Molecular Formula C8H14N2O4Pt
CAS Number 61825-94-3
SMILES [H][N]1([H])[C@@H]2CCCC[C@H]2[N]([H])([H])[Pt]11OC(=O)C(=O)O1
External Links
DRUGBANK DB00526
T3DB T3D2674
PubChem Compound 6857599
PDR 515
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 100.0 % 100 % intravenous injection, IV; DRUGBANK
C Max 814.0 ng/ml 0.814 mcg/ml intravenous injection, IV; DRUGBANK
C Max 0.33 mg Pt/ml 0.33(0.28-0.38) mg Pt/ml intravenous infusion, IV in drop; The Pharmacological Basis of Therapeutics
C Max 0.008000 mg Pt/ml 0.008(0.004-0.014) mg Pt/ml intravenous infusion, IV in drop; Derivative; The Pharmacological Basis of Therapeutics
Clearance 13.5 L/h 10.0-17 L/h Renal clearance; DRUGBANK
Clearance 2.9 L/h/kg 49(41-64) ml/min/kg The Pharmacological Basis of Therapeutics
Clearance 0.006000 L/h/kg 0.1 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 440.0 L 440.0 L intravenous injection, IV; Single dose; DRUGBANK
Volume of Distribution 1.5 L/kg 1.5(1.1-2.1) L/kg The Pharmacological Basis of Therapeutics
Volume of Distribution 0.50 L/kg 0.5 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 0.43 h 0.43 h distribution half-life; DRUGBANK
Half-life 16.8 h 16.8 h elimination half-life; DRUGBANK
Half-life 391.0 h 391 h terminal half-life; DRUGBANK
Half-life 0.32 h 0.32(0.27-0.46) h distribution half-life; The Pharmacological Basis of Therapeutics
Half-life 17.0 h 17 h elimination half-life; The Pharmacological Basis of Therapeutics
Half-life 391.0 h 391 h terminal half-life; The Pharmacological Basis of Therapeutics
Half-life 58.9 h 58.92 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 54.0 % ~54 % Urinary excretion; DRUGBANK
Eliminate Route 2.0 % ~2 % Faeces excretion; DRUGBANK
Protein Binding 90.0 % >90 % plasma proteins; DRUGBANK
Protein Binding 90.0 % 90 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adolescents 130.0 mg/m2 130 mg/m2 intravenous injection, IV Eloxatin oxaliplatin PDR
Max dose for elderly 130.0 mg/m2 130 mg/m2 intravenous injection, IV Eloxatin oxaliplatin PDR

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1