Basic Information
| Drug ID | DDPD00524 |
|
| Drug Name | Metolazone | |
| Molecular Weight | 365.835 | |
| Molecular Formula | C16H16ClN3O3S | |
| CAS Number | 17560-51-9 | |
| SMILES | CC1NC2=CC(Cl)=C(C=C2C(=O)N1C1=CC=CC=C1C)S(N)(=O)=O | |
| External Links | ||
| DRUGBANK | DB00524 | |
| PubChem Compound | 4170 | |
| PDR | 3455 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.5 | - | 2.5 | - | DRUGBANK |
| Melting Point | 256.0 | ℃ | 256 | ℃ | PhysProp |
| Water Solubility | 60.3 | mg/L | 60.3 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| Log S | -3.78 | - | -3.78 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 3.0 | h | 2-4 | h | PO, oral; | DRUGBANK |
| Metabolic | 0 | % | ~0 | % | DRUGBANK | Metabolic | 52.5 | % | 10-95 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Clearance | 0.0840 | L/h/kg | 1.4 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.6 | L/kg | 1.6 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 14.0 | h | ~14 | h | DRUGBANK | Half-life | 20.0 | h | 20 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 60.0 | % | 50-70 | % | serum albumin; | DRUGBANK | Protein Binding | 33.0 | % | ≤33 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 0.4 | mg/kg/day | 0.4 | mg/kg/day | PO, oral | Metolazone | metolazone | PDR |
| Max dose for adults | 5.0 | mg/day | 5 | mg/day | PO, oral | Metolazone | metolazone | PDR |
| Max dose for adults | 20.0 | mg/day | 20 | mg/day | PO, oral | Metolazone | metolazone | PDR |
| Max dose for adults | 150.0 | mg | 150 | mg | PO, oral | Metolazone | metolazone | PDR |
| Max dose for elderly | 5.0 | mg/day | 5 | mg/day | PO, oral | Metolazone | metolazone | PDR |
| Max dose for elderly | 20.0 | mg/day | 20 | mg/day | PO, oral | Metolazone | metolazone | PDR |
| Max dose for elderly | 150.0 | mg | 150 | mg | PO, oral | Metolazone | metolazone | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1