Basic Information
| Drug ID | DDPD00520 |
|
| Drug Name | Caspofungin | |
| Molecular Weight | 1093.3131 | |
| Molecular Formula | C52H88N10O15 | |
| CAS Number | 162808-62-0 | |
| SMILES | CCC(C)CC(C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC1=O)[C@@H](C)O)[C@H](O)[C@@H](O)C1=CC=C(O)C=C1)[C@H](O)CCN | |
| External Links | ||
| DRUGBANK | DB00520 | |
| PubChem Compound | 3035406 | |
| PDR | 333 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.0 | - | 0.0 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| C Max | 8700.0 | ng/ml | 8.7(7.9-9.6) | mcg/ml | intravenous injection, IV; | The Pharmacological Basis of Therapeutics | |
| Clearance | 0.72 | L/h | 12.0 | ml/min | intravenous injection, IV; | DRUGBANK | Clearance | 0.009600 | L/h/kg | 0.16(0.14-0.18) | ml/min/kg | hepatopathy，LD ↓ ; | The Pharmacological Basis of Therapeutics | Clearance | 0.008400 | L/h/kg | 0.14 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.12 | L/kg | 0.12 | L/kg | Total volume of distribution; | The Pharmacological Basis of Therapeutics | Volume of Distribution | 0.13 | L/kg | 0.13 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 10.0 | h | 9-11 | h | DRUGBANK | Half-life | 9.6 | h | 9.6±0.8 | h | The Pharmacological Basis of Therapeutics | Half-life | 25.0 | h | >25 | h | terminal half-life; | The Pharmacological Basis of Therapeutics | Half-life | 27.0 | h | 27 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 35.0 | % | 35 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 41.0 | % | 41 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 2.0 | % | ~2 | % | Urinary excretion; Unchanged drug; | The Pharmacological Basis of Therapeutics |
| Protein Binding | 97.0 | % | 97 | % | DRUGBANK | Protein Binding | 96.5 | % | 96.5 | % | The Pharmacological Basis of Therapeutics |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 25.0 | mg/m2/day | 25 | mg/m2/day | intravenous injection, IV | Cancidas | caspofungin acetate | PDR |
| Max dose for infants | 70.0 | mg/m2/day | 70 | mg/m2/day | intravenous injection, IV | Cancidas | caspofungin acetate | PDR |
| Max dose for infants | 25.0 | mg/m2/day | 25 | mg/m2/day | intravenous injection, IV | Cancidas | caspofungin acetate | PDR |
| Max dose for children | 70.0 | mg/m2/day | 70 | mg/m2/day | intravenous injection, IV | Cancidas | caspofungin acetate | PDR |
| Max dose for adolescents | 70.0 | mg/m2/day | 70 | mg/m2/day | intravenous injection, IV | Cancidas | caspofungin acetate | PDR |
| Max dose for adults | 70.0 | mg/day | 70 | mg/day | intravenous injection, IV | Cancidas | caspofungin acetate | PDR |
| Max dose for adults | 150.0 | mg/day | 150 | mg/day | intravenous injection, IV | Cancidas | caspofungin acetate | PDR |
| Max dose for geriatric | 70.0 | mg/day | 70 | mg/day | intravenous injection, IV | Cancidas | caspofungin acetate | PDR |
| Max dose for geriatric | 150.0 | mg/day | 150 | mg/day | intravenous injection, IV | Cancidas | caspofungin acetate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1