Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00519 ...
Drug Name Trandolapril
Molecular Weight 430.5372
Molecular Formula C24H34N2O5
CAS Number 87679-37-6
SMILES [H][C@@]12C[C@H](N(C(=O)[C@H](C)N[C@@H](CCC3=CC=CC=C3)C(=O)OCC)[C@@]1([H])CCCC2)C(O)=O
External Links
DRUGBANK DB00519
PubChem Compound 5484727
PDR 19
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.5 - 3.5 - DRUGBANK
Melting Point 121.0 ℃ 119-123 ℃ DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 50.0 % ~40-60 % DRUGBANK
Bioavailability 9.0 % 4-14 % DRUGBANK
Clearance 52.0 L/h 52.0 L/h intravenous injection, IV; DRUGBANK
Clearance 0.75 L/h/kg 12.5 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 18.0 L 18.0 L DRUGBANK
Volume of Distribution 0.25 L/kg 0.25 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 6.0 h 6 h elimination half-life; DRUGBANK
Half-life 10.0 h 10 h elimination half-life; DRUGBANK
Half-life 20.0 h 16-24 h effective half-life; DRUGBANK
Half-life 0.26 h 0.26 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 4875.0 mg/kg 4875.0 mg/kg PO, oral; female mouse; DRUGBANK
Toxicity LD50 3990.0 mg/kg 3990.0 mg/kg PO, oral; male mouse; DRUGBANK
Eliminate Route 66.0 % ~66 % Faeces excretion; PO, oral; DRUGBANK
Eliminate Route 33.0 % ~33 % Urinary excretion; PO, oral; DRUGBANK
Protein Binding 80.0 % ~80 % Plasma Concentration → ; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 8.0 mg/day 8 mg/day PO, oral Mavik trandolapril PDR
Max dose for adults 4.0 mg/day 4 mg/day PO, oral Mavik trandolapril PDR
Max dose for elderly 8.0 mg/day 8 mg/day PO, oral Mavik trandolapril PDR
Max dose for elderly 4.0 mg/day 4 mg/day PO, oral Mavik trandolapril PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1