Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00514 ...
Drug Name Dextromethorphan
Molecular Weight 271.404
Molecular Formula C18H25NO
CAS Number 125-71-3
SMILES [H][C@]12CCCC[C@]11CCN(C)[C@H]2CC2=C1C=C(OC)C=C2
External Links
DRUGBANK DB00514
T3DB T3D2815
PubChem Compound 5360696
PDR 2941
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.6 - 3.6 - DRUGBANK
Melting Point 123.0 ℃ 122-124 ℃ Schnider, O. and Grussner, A,; US. Patent 2,676,177; April 20, 1954; assigned to Hoffrnann-La Roche Inc.
Water Solubility 74.7 mg/L 74.7 mg/L DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 17.8 ng.h/ml 17.8 ng.h/ml PO, oral; DRUGBANK
C Max 2.9 ng/ml 2.9 ng/ml PO, oral; DRUGBANK
C Max 5.2 ng/ml 5.2±1.8 ng/ml PO, oral; poor metabolizers, PM; The Pharmacological Basis of Therapeutics
C Max 33.0 ng/ml 33±8.2 ng/ml PO, oral; extensive metabolizers, EM; The Pharmacological Basis of Therapeutics
C Max 879.0 ng/ml 879±60 ng/ml PO, oral; Drug form; poor metabolizers, PM; The Pharmacological Basis of Therapeutics
T Max 2.9 h 2.86 h PO, oral; DRUGBANK
T Max 2.3 h 2-2.5 h The Pharmacological Basis of Therapeutics
Clearance 94.5 L/h/kg 1575±658 ml/min/kg apparent clearance; PO, oral; extensive metabolizers, EM; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 0.23 L/h/kg ~3.9±1.4 ml/min/kg apparent clearance; PO, oral; poor metabolizers, PM; normal,healthy; The Pharmacological Basis of Therapeutics
Half-life 4.5 h 3-6 h DRUGBANK
Half-life 3.4 h 3.4±0.5 h extensive metabolizers, EM; PO, oral; The Pharmacological Basis of Therapeutics
Half-life 29.5 h 29.5±8.4 h poor metabolizers, PM; PO, oral; The Pharmacological Basis of Therapeutics
Toxicity LD50 165.0 mg/kg 165.0 mg/kg mouse; T3DB
Toxicity LD50 350.0 mg/kg 350.0 mg/kg Rattus, Rat; T3DB
Eliminate Route 0.19 % 0.19±0.21 % Urinary excretion; adults; normal,healthy; extensive metabolizers, EM; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Eliminate Route 11.1 % 11.1±3 % Urinary excretion; adults; normal,healthy; poor metabolizers, PM; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 65.0 % 60-70 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 60.0 mg/day 60 mg/day PO, oral Children's Robitussin dextromethorphan hydrobromide PDR
Max dose for children 30.0 mg/day 30 mg/day PO, oral Children's Robitussin dextromethorphan hydrobromide PDR
Max dose for children 30.0 mg/day 30 mg/day PO, oral Children's Robitussin dextromethorphan hydrobromide PDR
Max dose for adolescents 120.0 mg/day 120 mg/day PO, oral Children's Robitussin dextromethorphan hydrobromide PDR
Max dose for adults 120.0 mg/day 120 mg/day PO, oral Children's Robitussin dextromethorphan hydrobromide PDR
Max dose for adults 960.0 mg/day 960 mg/day PO, oral Children's Robitussin dextromethorphan hydrobromide PDR
Max dose for geriatric 120.0 mg/day 120 mg/day PO, oral Children's Robitussin dextromethorphan hydrobromide PDR
Max dose for geriatric 960.0 mg/day 960 mg/day PO, oral Children's Robitussin dextromethorphan hydrobromide PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1