Basic Information
| Drug ID | DDPD00513 |
|
| Drug Name | Aminocaproic acid | |
| Molecular Weight | 131.1729 | |
| Molecular Formula | C6H13NO2 | |
| CAS Number | 60-32-2 | |
| SMILES | NCCCCCC(O)=O | |
| External Links | ||
| DRUGBANK | DB00513 | |
| PubChem Compound | 564 | |
| PDR | 1954 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -2.95 | - | -2.95 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 205.0 | ℃ | 205 | ℃ | PhysProp |
| Water Solubility | 505000.0 | mg/L | 505000 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| pKa | 4.43 | - | 4.43 | - | KORTUM,G ET AL (1961) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 100.0 | % | 100.0 | % | Oral single dose; | DRUGBANK |
| Metabolic | 65.0 | % | 65 | % | Urinary excretion; Unchanged drug; | DRUGBANK | Metabolic | 11.0 | % | 11 | % | DRUGBANK |
| Clearance | 10.1 | L/h | 169.0 | ml/min | DRUGBANK | |
| Volume of Distribution | 23.1 | L | 23.1±6.6 | L | DRUGBANK | |
| Half-life | 2.0 | h | ~2 | h | elimination half-life; | DRUGBANK |
| Toxicity LD50 | 3000.0 | mg/kg | 3.0 | g/kg | intravenous injection, IV; mouse; | DRUGBANK | Toxicity LD50 | 12000.0 | mg/kg | 12.0 | g/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 3200.0 | mg/kg | 3.2 | g/kg | intravenous injection, IV; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 16400.0 | mg/kg | 16.4 | g/kg | intravenous injection, IV; mouse; | DRUGBANK |
| Toxicity Lethal Dose | 2300.0 | mg/kg | 2.3 | g/kg | intravenous infusion, IV in drop; dog; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 30000.0 | mg/day | 30 | g/day | PO, oral;intravenous injection, IV; | Amicar | aminocaproic acid | PDR |
| Max dose for adults | 36000.0 | mg/day | 36 | g/day | PO, oral;intravenous injection, IV; | Amicar | aminocaproic acid | PDR |
| Max dose for elderly | 30000.0 | mg/day | 30 | g/day | PO, oral;intravenous injection, IV; | Amicar | aminocaproic acid | PDR |
| Max dose for elderly | 36000.0 | mg/day | 36 | g/day | PO, oral;intravenous injection, IV; | Amicar | aminocaproic acid | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1