Basic Information
| Drug ID | DDPD00512 |
|
| Drug Name | Vancomycin | |
| Molecular Weight | 1449.254 | |
| Molecular Formula | C66H75Cl2N9O24 | |
| CAS Number | 1404-90-6 | |
| SMILES | CN[C@H](CC(C)C)C(=O)N[C@@H]1[C@H](O)C2=CC=C(OC3=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@H]4C[C@](C)(N)[C@H](O)[C@H](C)O4)C4=CC(=C3)[C@@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N[C@@H]1C3=CC(=C(O)C=C3)C3=C(O)C=C(O)C=C3[C@H](NC(=O)[C@@H](NC1=O)[C@H](O)C1=CC(Cl)=C(O4)C=C1)C(O)=O)C(Cl)=C2 | |
| External Links | ||
| DRUGBANK | DB00512 | |
| T3DB | T3D3543 | |
| PubChem Compound | 14969 | |
| PDR | 3535 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -3.1 | - | -3.1 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Absorption | 60.0 | % | ~60 | % | DRUGBANK | ||
| C Max | 48500.0 | ng/ml | 18.5(15-25) | mcg/ml | intravenous infusion, IV in drop; | The Pharmacological Basis of Therapeutics | C Max | 48500.0 | ng/ml | 18.5(15-25) | mcg/ml | intravenous infusion, IV in drop; staphylococcal infections; streptococcal infections; | The Pharmacological Basis of Therapeutics |
| Metabolic | 77.5 | % | 75-80 | % | Urinary excretion; Unchanged drug; | DRUGBANK | |
| Clearance | 0.0580 | L/h/kg | 0.058 | L/kg/h | Plasma clearance; | DRUGBANK | Clearance | 0.0780 | L/h/kg | 1.3 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.70 | L/kg | 0.4-1 | L/kg | DRUGBANK | Volume of Distribution | 0.39 | L/kg | 0.39±0.06 | L/kg | Obesity ↓ ;RD, renal impairment, Renal disease，including uremia → ;CPBS → ; | The Pharmacological Basis of Therapeutics | Volume of Distribution | 0.54 | L/kg | 0.54 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 6.0 | h | ~6(4-11) | h | normal renal function; patients; | DRUGBANK | Half-life | 180.0 | h | 7.5 | day | elimination half-life; anephric; patients; | DRUGBANK | Half-life | 5.6 | h | 5.6±1.8 | h | RD, renal impairment, Renal disease，including uremia ↑ ;Obesity ↓ ;Age ↑ ; | The Pharmacological Basis of Therapeutics | Half-life | 6.5 | h | 6.5 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 5000.0 | mg/kg | 5000.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 319.0 | mg/kg | 319.0 | mg/kg | intravenous injection, IV; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 400.0 | mg/kg | 400.0 | mg/kg | intravenous injection, IV; mouse; | DRUGBANK | Toxicity LD50 | 5000.0 | mg/kg | 5000.0 | mg/kg | PO, oral; mouse; | T3DB | Toxicity LD50 | 319.0 | mg/kg | 319.0 | mg/kg | intravenous injection, IV; Rattus, Rat; | T3DB | Toxicity LD50 | 400.0 | mg/kg | 400.0 | mg/kg | intravenous injection, IV; mouse; | T3DB |
| Eliminate Route | 77.5 | % | ~75-80 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 79.0 | % | 79±11 | % | Urinary excretion; Unchanged drug; | The Pharmacological Basis of Therapeutics |
| Protein Binding | 50.0 | % | ~50 | % | DRUGBANK | Protein Binding | 30.0 | % | 30±11 | % | RD, renal impairment, Renal disease，including uremia → ; | The Pharmacological Basis of Therapeutics |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 30.0 | mg/kg/day | 30 | mg/kg/day | intravenous injection, IV | Vancomycin Hydrochloride for Injection | vancomycin hydrochloride | PDR |
| Max dose for neonates | 20.0 | mg/kg/day | 20 | mg/kg/day | intravenous injection, IV | Vancomycin Hydrochloride for Injection | vancomycin hydrochloride | PDR |
| Max dose for infants | 40.0 | mg/kg/day | 40 | mg/kg/day | PO, oral;intravenous injection, IV; | Vancomycin Hydrochloride for Injection | vancomycin hydrochloride | PDR |
| Max dose for infants | 60.0 | mg/kg/day | 60 | mg/kg/day | intravenous injection, IV | Vancomycin Hydrochloride for Injection | vancomycin hydrochloride | PDR |
| Max dose for children | 40.0 | mg/kg/day | 40 | mg/kg/day | intravenous injection, IV | Vancomycin Hydrochloride for Injection | vancomycin hydrochloride | PDR |
| Max dose for children | 2000.0 | mg/day | 2 | g/day | PO, oral | Vancomycin Hydrochloride for Injection | vancomycin hydrochloride | PDR |
| Max dose for children | 60.0 | mg/kg/day | 60 | mg/kg/day | intravenous injection, IV | Vancomycin Hydrochloride for Injection | vancomycin hydrochloride | PDR |
| Max dose for adolescents | 40.0 | mg/kg/day | 40 | mg/kg/day | intravenous injection, IV | Vancomycin Hydrochloride for Injection | vancomycin hydrochloride | PDR |
| Max dose for adolescents | 2000.0 | mg/day | 2 | g/day | PO, oral | Vancomycin Hydrochloride for Injection | vancomycin hydrochloride | PDR |
| Max dose for adolescents | 60.0 | mg/kg/day | 60 | mg/kg/day | intravenous injection, IV | Vancomycin Hydrochloride for Injection | vancomycin hydrochloride | PDR |
| Max dose for adults | 2000.0 | mg/day | 2 | g/day | PO, oral;intravenous injection, IV; | Vancomycin Hydrochloride for Injection | vancomycin hydrochloride | PDR |
| Max dose for geriatric | 2000.0 | mg/day | 2 | g/day | PO, oral;intravenous injection, IV; | Vancomycin Hydrochloride for Injection | vancomycin hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1