Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00503 ...
Drug Name Ritonavir
Molecular Weight 720.944
Molecular Formula C37H48N6O5S2
CAS Number 155213-67-5
SMILES CC(C)[C@H](NC(=O)N(C)CC1=CSC(=N1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)OCC1=CN=CS1)CC1=CC=CC=C1
External Links
DRUGBANK DB00503
PubChem Compound 392622
PDR 22
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.9 - 3.9 - DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
C Max 11000.0 ng/ml 11±4 mcg/ml PO, oral; The Pharmacological Basis of Therapeutics
T Max 3.0 h 2-4 h PO, oral; DRUGBANK
T Max 3.0 h 2-4 h PO, oral; The Pharmacological Basis of Therapeutics
Clearance 8.8 L/h 8.8±3.2 L/h Total clearance; PO, oral; DRUGBANK
Clearance 0.10 L/h <0.1 L/h DRUGBANK
Clearance 0.0720 L/h/kg 1.2±0.4 ml/min/kg apparent clearance; Single dose; hydrolysis; The Pharmacological Basis of Therapeutics
Clearance 0.13 L/h/kg 2.1±0.8 ml/min/kg apparent clearance; Multiple dose; hydrolysis; Children ↑ ;hepatopathy，LD ↓ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.41 L/kg 0.41±0.25 L/kg DRUGBANK
Volume of Distribution 0.41 L/kg 0.41±0.25 L/kg Apparent volume of distribution; Single dose; hydrolysis; The Pharmacological Basis of Therapeutics
Half-life 4.0 h 3-5 h DRUGBANK
Half-life 4.0 h 3-5 h PO, oral; moderate renal function ↑ ; The Pharmacological Basis of Therapeutics
Toxicity LD50 2500.0 mg/kg >2500 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 11.3 % ~11.3±2.3 % Urinary excretion; Oral single dose; DRUGBANK
Eliminate Route 86.4 % 86.4±2.9 % Faeces excretion; Oral single dose; DRUGBANK
Eliminate Route 3.5 % 3.5±1.8 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 98.5 % ~98-99 % DRUGBANK
Protein Binding 98.5 % 98-99 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 800.0 mg/m2/day 800 mg/m2/day PO, oral Norvir Capsules ritonavir PDR
Max dose for infants 800.0 mg/m2/day 800 mg/m2/day PO, oral Norvir Capsules ritonavir PDR
Max dose for infants 1200.0 mg/day 1200 mg/day PO, oral Norvir Capsules ritonavir PDR
Max dose for children 800.0 mg/m2/day 800 mg/m2/day PO, oral Norvir Capsules ritonavir PDR
Max dose for children 1200.0 mg/day 1200 mg/day PO, oral Norvir Capsules ritonavir PDR
Max dose for adolescents 1200.0 mg/day 1200 mg/day PO, oral Norvir Capsules ritonavir PDR
Max dose for geriatric 1200.0 mg/day 1200 mg/day PO, oral Norvir Capsules ritonavir PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1