Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00502 ...
Drug Name Haloperidol
Molecular Weight 375.864
Molecular Formula C21H23ClFNO2
CAS Number 52-86-8
SMILES OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C1=CC=C(Cl)C=C1
External Links
DRUGBANK DB00502
T3DB T3D2576
PubChem Compound 3559
PDR 1564
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 4.3 - 4.3 - https://pubchem.ncbi.nlm.nih.gov/compound/haloperidol
Melting Point 148.0 ℃ 148 ℃ MSDS
Water Solubility 14.0 mg/L 14 mg/L https://pubchem.ncbi.nlm.nih.gov/compound/haloperidol
pKa 8.66 - 8.66 - EL TAYAR,N ET AL. (1985)
Log S -4.43 - -4.43 - https://pubchem.ncbi.nlm.nih.gov/compound/haloperidol

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 43730.0 ng.h/ml 43.73（14.89-120.96） ug.h/ml PO, oral; DRUGBANK
Bioavailability 57.5 % 40-75 % PO, oral; DRUGBANK
Bioavailability 60.0 % 60±18 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 22.0 ng/ml 22±18 ng/ml IM,intramuscular injection; The Pharmacological Basis of Therapeutics
C Max 9.2 ng/ml 9.2±4.4 ng/ml Oral single dose; The Pharmacological Basis of Therapeutics
T Max 3.9 h 1.7-6.1 h PO, oral; DRUGBANK
T Max 0.33 h 20 min IM,intramuscular injection; DRUGBANK
T Max 0.56 h 33.8 min IM,intramuscular injection; schizophrenia; DRUGBANK
T Max 0.60 h 0.6±0.1 h IM,intramuscular injection; The Pharmacological Basis of Therapeutics
T Max 1.7 h 1.7±3.2 h Oral single dose; The Pharmacological Basis of Therapeutics
Metabolic 1.0 % 1 % Urinary excretion; Unchanged drug; DRUGBANK
Clearance 0.55 L/h/kg 0.39-0.708 L/h/kg Plasma clearance; intravenous injection, IV; DRUGBANK
Clearance 141.7 L/h 141.65 L/h PO, oral; DRUGBANK
Clearance 1.2 L/h/kg 0.9-1.5 L/h/kg extravascular administration; poor metabolizers, PM ↓ ; DRUGBANK
Clearance 0.71 L/h/kg 11.8±2.9 ml/min/kg Children ↑ ;Elderly ↓ ;Somking ↑ ; The Pharmacological Basis of Therapeutics
Clearance 0.47 L/h/kg 7.8 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 15.6 L/kg 9.5-21.7 L/kg Apparent volume of distribution; DRUGBANK
Volume of Distribution 18.0 L/kg 18±7 L/kg The Pharmacological Basis of Therapeutics
Volume of Distribution 17.0 L/kg 17 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 25.6 h 14.5-36.7 h PO, oral; DRUGBANK
Half-life 20.7 h 20.7 h IM,intramuscular injection; DRUGBANK
Half-life 18.0 h 18±5 h Children ↓ ; The Pharmacological Basis of Therapeutics
Half-life 67.0 h 67±51 h The Pharmacological Basis of Therapeutics
Half-life 70.0 h 70 h terminal half-life; The Pharmacological Basis of Therapeutics
Half-life 35.0 h 35 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 71.0 mg/kg 71.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 128.0 mg/kg 128.0 mg/kg PO, oral; Rattus, Rat; T3DB
Toxicity LD50 71.0 mg/kg 71.0 mg/kg PO, oral; mouse; T3DB
Toxicity LD50 90.0 mg/kg 90.0 mg/kg PO, oral; dog; T3DB
Toxicity LD50 165.0 mg/kg 165.0 mg/kg PO, oral; Rattus, Rat; T3DB
Eliminate Route 30.0 % ~30 % Urinary excretion; Oral single dose; DRUGBANK
Eliminate Route 1.0 % 1 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 92.0 % 92±2 % Elderly → ;Children → ;Hepatic cirrhosis, cirr ↑ ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 0.15 mg/kg/day 0.15 mg/kg/day PO, oral Haloperidol Oral Solution haloperidol PDR
Max dose for children 6.0 mg/day 6 mg/day PO, oral Haloperidol Oral Solution haloperidol PDR
Max dose for children 15.0 mg/day 15 mg/day PO, oral Haloperidol Oral Solution haloperidol PDR
Max dose for adolescents 15.0 mg/day 15 mg/day PO, oral Haloperidol Oral Solution haloperidol PDR
Max dose for adolescents 100.0 mg/day 100 mg/day PO, oral Haloperidol Oral Solution haloperidol PDR
Max dose for adolescents 0.15 mg/kg/day 0.15 mg/day/kg PO, oral Haloperidol Oral Solution haloperidol PDR
Max dose for adolescents 6.0 mg/day 6 mg/day PO, oral Haloperidol Oral Solution haloperidol PDR
Max dose for adults 100.0 mg/day 100 mg/day PO, oral Haloperidol Oral Solution haloperidol PDR
Max dose for adults 20.0 mg/day 20 mg/day IM,intramuscular injection Haloperidol Oral Solution haloperidol PDR
Max dose for adults 15.0 mg/day 450 mg/month IM,intramuscular injection Haloperidol Oral Solution haloperidol PDR
Max dose for geriatric 100.0 mg/day 100 mg/day Liquid Haloperidol Oral Solution haloperidol PDR
Max dose for geriatric 20.0 mg/day 20 mg/day IM,intramuscular injection Haloperidol Oral Solution haloperidol PDR
Max dose for geriatric 15.0 mg/day 450 mg/month IM,intramuscular injection Haloperidol Oral Solution haloperidol PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1