Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00501 ...
Drug Name Cimetidine
Molecular Weight 252.339
Molecular Formula C10H16N6S
CAS Number 51481-61-9
SMILES CN\C(NCCSCC1=C(C)NC=N1)=N\C#N
External Links
DRUGBANK DB00501
T3DB T3D2810
PubChem Compound 2756
PDR 1962
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Caco-2 Permeability -5.89 - -5.89 - ADME Research, USCD
Log P 0.4 - 0.4 - HANSCH,C ET AL. (1995)
Melting Point 142.0 ℃ 142 ℃ PhysProp
Water Solubility 9380.0 mg/L 9380 mg/L MCFARLAND,JW ET AL. 2001)
pKa 6.8 - 6.8 - TOMLINSON,E & HAFKENSCHEID,TL (1986)
Log S -1.35 - -1.35 - ADME Research, USCD

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 65.0 % 60-70 % DRUGBANK
Bioavailability 60.0 % 60±23 % PO, oral; peptic ulcer disease; The Pharmacological Basis of Therapeutics
C Max 2500.0 ng/ml 2-3 mcg/ml Oral single dose; fasting; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.0 h 0.5-1.5 h Oral single dose; fasting; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 0.50 L/h/kg 8.3±2.0 ml/min/kg Elderly ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ;Hepatitis, Hep → ;Cystic fibrosis ↑ ;Burn ↑ ;Ulcer → ; The Pharmacological Basis of Therapeutics
Clearance 0.49 L/h/kg 8.1 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 1.0 L/kg 1.0±0.2 L/kg Hepatitis, Hep → ;RD, renal impairment, Renal disease，including uremia → ;Burn → ;Ulcer → ;Cystic fibrosis ↑ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.2 L/kg 1.2 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.0 h 2 h DRUGBANK
Half-life 2.0 h 2.0±0.3 h RD, renal impairment, Renal disease，including uremia ↑ ;Ulcer → ;Hepatic cirrhosis, cirr → ;Cystic fibrosis → ;Burn ↓ ; The Pharmacological Basis of Therapeutics
Half-life 2.2 h 2.2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 62.0 % 62±20 % Urinary excretion; peptic ulcer disease; human, homo sapiens; Unchanged drug; Hepatic cirrhosis, cirr → ;Cystic fibrosis → ; The Pharmacological Basis of Therapeutics
Protein Binding 17.5 % 15-20 % DRUGBANK
Protein Binding 19.0 % 19(13-25) % peptic ulcer disease; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 20.0 mg/kg/day 20 mg/kg/day PO, oral;intravenous injection, IV; Cimetidine Tablets cimetidine PDR
Max dose for infants 40.0 mg/kg/day 40 mg/kg/day PO, oral;intravenous injection, IV; Cimetidine Tablets cimetidine PDR
Max dose for children 40.0 mg/kg/day 40 mg/kg/day PO, oral;intravenous injection, IV; Cimetidine Tablets cimetidine PDR
Max dose for adolescents 40.0 mg/kg/day 40 mg/kg/day PO, oral Cimetidine Tablets cimetidine PDR
Max dose for adolescents 1200.0 mg/day 1200 mg/day PO, oral;intravenous injection, IV; Cimetidine Tablets cimetidine PDR
Max dose for adolescents 1600.0 mg/day 1600 mg/day PO, oral Cimetidine Tablets cimetidine PDR
Max dose for adolescents 2400.0 mg/day 2400 mg/day PO, oral Cimetidine Tablets cimetidine PDR
Max dose for adults 1200.0 mg/day 1200 mg/day PO, oral Cimetidine Tablets cimetidine PDR
Max dose for adults 1600.0 mg/day 1600 mg/day PO, oral Cimetidine Tablets cimetidine PDR
Max dose for adults 2400.0 mg/day 2400 mg/day PO, oral Cimetidine Tablets cimetidine PDR
Max dose for geriatric 1200.0 mg/day 1200 mg/day PO, oral Cimetidine Tablets cimetidine PDR
Max dose for geriatric 1600.0 mg/day 1600 mg/day PO, oral Cimetidine Tablets cimetidine PDR
Max dose for geriatric 2400.0 mg/day 2400 mg/day PO, oral Cimetidine Tablets cimetidine PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1