Basic Information
| Drug ID | DDPD00500 |
|
| Drug Name | Tolmetin | |
| Molecular Weight | 257.2845 | |
| Molecular Formula | C15H15NO3 | |
| CAS Number | 26171-23-3 | |
| SMILES | CN1C(CC(O)=O)=CC=C1C(=O)C1=CC=C(C)C=C1 | |
| External Links | ||
| DRUGBANK | DB00500 | |
| PubChem Compound | 5509 | |
| PDR | 3671 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.79 | - | 2.79 | - | SANGSTER (1993) |
| Melting Point | 156.0 | ℃ | 156 | ℃ | PhysProp |
| Water Solubility | 222.0 | mg/L | 222 | mg/L | DRUGBANK |
| pKa | 3.5 | - | 3.5 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 100.0 | % | ~100 | % | PO, oral; | DRUGBANK |
| T Max | 0.75 | h | 0.5-1 | h | PO, oral; | DRUGBANK |
| Half-life | 1.5 | h | 1-2 | h | elimination half-life; | DRUGBANK | Half-life | 5.0 | h | ~5 | h | terminal half-life; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 30.0 | mg/kg/day | 30 | mg/kg/day | Tablet,PO，oral | Tolmetin 600mg Tablets | tolmetin sodium | PDR |
| Max dose for children | 1800.0 | mg/day | 1800 | mg/day | Tablet,PO，oral | Tolmetin 600mg Tablets | tolmetin sodium | PDR |
| Max dose for adolescents | 30.0 | mg/kg/day | 30 | mg/kg/day | Tablet,PO，oral | Tolmetin 600mg Tablets | tolmetin sodium | PDR |
| Max dose for adolescents | 1800.0 | mg/day | 1800 | mg/day | Tablet,PO，oral | Tolmetin 600mg Tablets | tolmetin sodium | PDR |
| Max dose for adults | 1800.0 | mg/day | 1800 | mg/day | Tablet,PO，oral | Tolmetin 600mg Tablets | tolmetin sodium | PDR |
| Max dose for elderly | 1800.0 | mg/day | 1800 | mg/day | Tablet,PO，oral | Tolmetin 600mg Tablets | tolmetin sodium | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1