Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00499 ...
Drug Name Flutamide
Molecular Weight 276.2118
Molecular Formula C11H11F3N2O3
CAS Number 13311-84-7
SMILES CC(C)C(=O)NC1=CC(=C(C=C1)[N+]([O-])=O)C(F)(F)F
External Links
DRUGBANK DB00499
T3DB T3D4768
PubChem Compound 3397
PDR 1554
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.35 - 3.35 - MORRIS,JJ ET AL. (1991)
Melting Point 112.0 ℃ 111.5-112.5 ℃ Gold, E.H.; U.S. Patent 3,847,988; November 12, 1974; assigned to Schering Corp.
Water Solubility 9.45 mg/L 9.45 mg/L DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 100.0 % 100.0 % DRUGBANK
C Max 110.0 ng/ml 0.11±0.21 mcg/ml PO, oral; Elderly; The Pharmacological Basis of Therapeutics
C Max 1600.0 ng/ml 1.6±0.59 mcg/ml PO, oral; Active metabolite; Elderly; The Pharmacological Basis of Therapeutics
T Max 1.3 h 1.3±0.7 h PO, oral; Elderly; The Pharmacological Basis of Therapeutics
T Max 1.9 h 1.9±0.6 h PO, oral; Active metabolite; Elderly; The Pharmacological Basis of Therapeutics
Clearance 16.8 L/h/kg 280.0 ml/min/kg apparent clearance; PO, oral; Male, men; Elderly; RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Half-life 6.0 h ~6 h elimination half-life; DRUGBANK
Half-life 7.8 h 7.8 h terminal half-life; PO, oral; The Pharmacological Basis of Therapeutics
Half-life 8.1 h 8.1 h terminal half-life; PO, oral; The Pharmacological Basis of Therapeutics
Eliminate Route 4.2 % 4.2 % Faeces excretion; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion; Elderly; Male, men; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 95.0 % 94-96 % DRUGBANK
Protein Binding 95.0 % 94-96 % Elderly; Male, men; human, homo sapiens; The Pharmacological Basis of Therapeutics
Protein Binding 93.0 % 92-94 % Metabolite; Elderly; Male, men; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 750.0 mg/day 750 mg/day PO, oral Flutamide flutamide PDR
Max dose for elderly 750.0 mg/day 750 mg/day PO, oral Flutamide flutamide PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1