Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00497 ...
Drug Name Oxycodone
Molecular Weight 315.3636
Molecular Formula C18H21NO4
CAS Number 76-42-6
SMILES COC1=C2O[C@H]3C(=O)CC[C@@]4(O)[C@H]5CC(C=C1)=C2[C@@]34CCN5C
External Links
DRUGBANK DB00497
T3DB T3D2809
PubChem Compound 5284603
PDR 1007
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 0.7 - 0.7 - https://www.ncbi.nlm.nih.gov/pubmed/8159633
Melting Point 219.0 ℃ 219 ℃ http://www.chemspider.com/Chemical-Structure.4447649.html
Water Solubility 166000.0 mg/L 166 mg/ml http://www.chemspider.com/Chemical-Structure.4447649.html

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 135.0 ng.h/ml 135.0 ng.h/ml PO, oral; patients; DRUGBANK
Bioavailability 73.5 % 60-87 % PO, oral; food; food → ; DRUGBANK
Bioavailability 73.5 % 60-87 % PO, oral; extended release formulation; The Pharmacological Basis of Therapeutics
Bioavailability 42.0 % 42±7 % PO, oral; immediate release formulation; The Pharmacological Basis of Therapeutics
C Max 11.5 ng/ml 11.5 ng/ml PO, oral; patients; DRUGBANK
C Max 15.1 ng/ml 15.1±4.7 ng/ml PO, oral; extended release formulation; The Pharmacological Basis of Therapeutics
C Max 15.5 ng/ml 15.5±4.5 ng/ml PO, oral; immediate release formulation; The Pharmacological Basis of Therapeutics
T Max 5.1 h 5.11 h PO, oral; patients; DRUGBANK
T Max 3.2 h 3.2±2.2 h PO, oral; extended release formulation; The Pharmacological Basis of Therapeutics
T Max 1.6 h 1.6±0.8 h PO, oral; immediate release formulation; The Pharmacological Basis of Therapeutics
Clearance 0.0840 L/h 1.4 ml/min Plasma clearance; DRUGBANK
Clearance 0.74 L/h/kg 12.4(9.2-15.4) ml/min/kg hydrolysis; normal,healthy; Male, men;  Female, women; The Pharmacological Basis of Therapeutics
Clearance 0.37 L/h/kg 6.1 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 2.6 L/kg 2.6 L/kg DRUGBANK
Volume of Distribution 2.0 L/kg 2.0(1.1-2.9) L/kg hydrolysis; normal,healthy; Male, men;  Female, women; The Pharmacological Basis of Therapeutics
Volume of Distribution 2.5 L/kg 2.5 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 3.2 h 3.2 h elimination half-life; DRUGBANK
Half-life 4.5 h 4.5 h extended release formulation; DRUGBANK
Half-life 5.8 h 5.8 h DRUGBANK
Half-life 8.8 h 8.8 h DRUGBANK
Half-life 9.0 h 9 h DRUGBANK
Half-life 2.6 h 2.6(2.1-3.1) h The Pharmacological Basis of Therapeutics
Half-life 5.0 h ~5 h extended release formulation; The Pharmacological Basis of Therapeutics
Half-life 5.5 h 5.5 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 320.0 mg/kg 320.0 mg/kg Intraperitoneal, IP; mouse; DRUGBANK
Toxicity LD50 426.0 mg/kg 426.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity TDLo 0.14 mg/kg 0.14 mg/kg PO, oral; human, homo sapiens; DRUGBANK
Toxicity TDLo 1.5 mg/kg 1.53 mg/kg subcutaneous injection, SC; Rattus, Rat; DRUGBANK
Protein Binding 45.0 % 45 % DRUGBANK
Protein Binding 45.0 % 45 % normal,healthy; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 288.0 mg/day 288 mg/day Capsule, PO, Oral Roxicodone oxycodone hydrochloride PDR
Max dose for adults 320.0 mg/day 320 mg/day PO, oral Roxicodone oxycodone hydrochloride PDR
Max dose for geriatric 288.0 mg/day 288 mg/day Capsule, PO, Oral Roxicodone oxycodone hydrochloride PDR
Max dose for geriatric 320.0 mg/day 320 mg/day PO, oral Roxicodone oxycodone hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1