Basic Information
| Drug ID | DDPD00493 |
|
| Drug Name | Cefotaxime | |
| Molecular Weight | 455.465 | |
| Molecular Formula | C16H17N5O7S2 | |
| CAS Number | 63527-52-6 | |
| SMILES | [H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\C1=CSC(N)=N1)C(O)=O | |
| External Links | ||
| DRUGBANK | DB00493 | |
| PubChem Compound | 5742673 | |
| PDR | 2858 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -0.5 | - | -0.5 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Metabolic | 28.0 | % | 20-36 | % | Renal metabolism; Unchanged drug; | DRUGBANK |
| Metabolic | 20.0 | % | 15-25 | % | Renal metabolism; Active metabolite; | DRUGBANK |
| Clearance | 0.16 | L/h/kg | 2.7 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.19 | L/kg | 0.19 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 1.0 | h | ~1 | h | DRUGBANK | |
| Half-life | 1.2 | h | 1.2 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 20000.0 | mg/kg | >20000 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Toxicity LD50 | 7000.0 | mg/kg | >7000 | mg/kg | intravenous injection, IV; Rattus, Rat; | DRUGBANK |
| Eliminate Route | 28.0 | % | ~20-36 | % | Urinary excretion; intravenous injection, IV; Unchanged drug; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 150.0 | mg/kg/day | 150 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Claforan | cefotaxime | PDR |
| Max dose for neonates | 200.0 | mg/kg/day | 200 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Claforan | cefotaxime | PDR |
| Max dose for neonates | 100.0 | mg/kg/day | 100 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Claforan | cefotaxime | PDR |
| Max dose for neonates | 150.0 | mg/kg/day | 150 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Claforan | cefotaxime | PDR |
| Max dose for infants | 180.0 | mg/kg/day | 180 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Claforan | cefotaxime | PDR |
| Max dose for infants | 300.0 | mg/kg/day | 300 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Claforan | cefotaxime | PDR |
| Max dose for children | 12000.0 | mg/day | 12 | g/day | intravenous injection, IV;IM,intramuscular injection; | Claforan | cefotaxime | PDR |
| Max dose for children | 180.0 | mg/kg/day | 180 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Claforan | cefotaxime | PDR |
| Max dose for children | 300.0 | mg/kg/day | 300 | mg/kg/day | intravenous injection, IV;IM,intramuscular injection; | Claforan | cefotaxime | PDR |
| Max dose for children | 12000.0 | mg/day | 12 | g/day | intravenous injection, IV;IM,intramuscular injection; | Claforan | cefotaxime | PDR |
| Max dose for adolescents | 12.0 | 12 | Claforan | cefotaxime | PDR | |||
| Max dose for adults | 12000.0 | mg/day | 12 | g/day | intravenous injection, IV;IM,intramuscular injection; | Claforan | cefotaxime | PDR |
| Max dose for geriatric | 12000.0 | mg/day | 12 | g/day | intravenous injection, IV;IM,intramuscular injection; | Claforan | cefotaxime | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1