Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00490 ...
Drug Name Buspirone
Molecular Weight 385.5031
Molecular Formula C21H31N5O2
CAS Number 36505-84-7
SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)C1=NC=CC=N1
External Links
DRUGBANK DB00490
T3DB T3D2807
PubChem Compound 2477
PDR 1523
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.63 - 2.63 - TAKACS-NOVAK,K 1995 (IN PRESS)
Melting Point 202.0 ℃ 201.5-202.5 ℃ Buspirone hydrochloride (B7148) - Sigma Aldrich Product Information Sheet

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 5.0 % 5.0 % PO, oral; DRUGBANK
Bioavailability 3.9 % 3.9±4.3 % PO, oral; Male, men; adults; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 3.5 ng/ml 1-6 ng/ml Oral single dose; DRUGBANK
C Max 1.7 ng/ml 1.66±0.21 ng/ml Oral single dose; Male, men; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.1 h 0.67-1.5 h Oral single dose; DRUGBANK
T Max 0.71 h 0.71±0.06 h Oral single dose; Male, men; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 1.7 L/h/kg 1.7 L/h/kg Total clearance; DRUGBANK
Clearance 1.7 L/h/kg 28.3±10.3 ml/min/kg apparent clearance; hydrolysis; normal,healthy; Male, men; adults; Hepatitis, Hep ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 5.3 L/kg 5.3 L/kg DRUGBANK
Volume of Distribution 5.3 L/kg 5.3±2.6 L/kg hydrolysis; normal,healthy; Male, men; adults; The Pharmacological Basis of Therapeutics
Half-life 2.5 h ~2-3 h elimination half-life; Single dose; DRUGBANK
Half-life 2.4 h 2.4±1.1 h normal,healthy; adults;  Female, women; Hepatic cirrhosis, cirr ↑ ;RD, renal impairment, Renal disease，including uremia ↑ ; The Pharmacological Basis of Therapeutics
Toxicity LD50 196.0 mg/kg 196.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 655.0 mg/kg 655.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 586.0 mg/kg 586.0 mg/kg PO, oral; dog; DRUGBANK
Toxicity LD50 356.0 mg/kg 356.0 mg/kg PO, oral; monkey; DRUGBANK
Toxicity LD50 136.0 mg/kg 136.0 mg/kg Intraperitoneal, IP; Rattus, Rat; DRUGBANK
Toxicity LD50 146.0 mg/kg 146.0 mg/kg Intraperitoneal, IP; mouse; DRUGBANK
Toxicity LD50 136.0 mg/kg 136.0 mg/kg PO, oral; Rattus, Rat; T3DB
Eliminate Route 46.0 % ~29-63 % Urinary excretion; DRUGBANK
Eliminate Route 28.0 % ~18-38 % Faeces excretion; DRUGBANK
Eliminate Route 0.10 % <0.1 % Urinary excretion; adults; Male, men; normal,healthy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 86.0 % ~86 % plasma proteins; high protein binding; DRUGBANK
Protein Binding 95.0 % >95 % adults; Male, men; normal,healthy; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 60.0 mg/day 60 mg/day PO, oral Buspirone Hydrochloride Tablets, USP, 7.5 mg buspirone hydrochloride PDR
Max dose for geriatric 60.0 mg/day 60 mg/day PO, oral Buspirone Hydrochloride Tablets, USP, 7.5 mg buspirone hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1