Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00485 ...
Drug Name Dicloxacillin
Molecular Weight 470.326
Molecular Formula C19H17Cl2N3O5S
CAS Number 3116-76-5
SMILES [H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)C1=C(C)ON=C1C1=C(Cl)C=CC=C1Cl)C(O)=O
External Links
DRUGBANK DB00485
PubChem Compound 18381
PDR 720
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.91 - 2.91 - HANSCH,C ET AL. (1995)
Water Solubility 3.63 mg/L 3.63 mg/L DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 67.5 % 50-85 % The Pharmacological Basis of Therapeutics
C Max 69000.0 ng/ml 47-91 mcg/ml PO, oral; fasting; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.3 h 1-1.5 h PO, oral; food; food ↓ ; DRUGBANK
T Max 1.1 h 0.5-1.6 h PO, oral; fasting; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 0.0960 L/h/kg 1.6±0.3 ml/min/kg Renal clearance; RD, renal impairment, Renal disease，including uremia ↓ ;Cystic fibrosis ↑ ; The Pharmacological Basis of Therapeutics
Clearance 0.12 L/h/kg 2 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.0860 L/kg 0.086±0.017 L/kg RD, renal impairment, Renal disease，including uremia ↑ ;Cystic fibrosis ↑ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.11 L/kg 0.11 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 0.70 h ~0.7 h elimination half-life; DRUGBANK
Half-life 0.70 h 0.70±0.07 h RD, renal impairment, Renal disease，including uremia ↑ ;Cystic fibrosis → ; The Pharmacological Basis of Therapeutics
Half-life 0.88 h 0.88 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 3579.0 mg/kg 3579.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 60.0 % 60±7 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 95.8 % 95.8±0.2 % Elderly ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ;Hepatic cirrhosis, cirr ↓ ;Cystic fibrosis → ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adolescents 4000.0 mg/day 4 g/day PO, oral Dicloxacillin Sodium dicloxacillin sodium PDR
Max dose for adults 4000.0 mg/day 4 g/day PO, oral Dicloxacillin Sodium dicloxacillin sodium PDR
Max dose for elderly 4000.0 mg/day 4 g/day PO, oral Dicloxacillin Sodium dicloxacillin sodium PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1