Basic Information
| Drug ID | DDPD00484 |
|
| Drug Name | Brimonidine | |
| Molecular Weight | 292.135 | |
| Molecular Formula | C11H10BrN5 | |
| CAS Number | 59803-98-4 | |
| SMILES | BrC1=C(NC2=NCCN2)C=CC2=NC=CN=C12 | |
| External Links | ||
| DRUGBANK | DB00484 | |
| T3DB | T3D3487 | |
| PubChem Compound | 2435 | |
| PDR | 3213 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Melting Point | 207.5 | ℃ | 207.5 | ℃ | Sandoz Canada Product Monograph |
| Water Solubility | 34000.0 | mg/L | 34 | mg/ml | Sandoz Canada Product Monograph |
| pKa | 7.78 | - | 7.78 | - | Sandoz Canada Product Monograph |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 0.42 | ng.h/ml | 417±264 | pg.h/ml | skin/dermal; | DRUGBANK |
| C Max | 0.0460 | ng/ml | 46±62 | pg/ml | skin/dermal; | DRUGBANK |
| T Max | 2.5 | h | 1-4 | h | ophthalmic administration; | DRUGBANK |
| Half-life | 3.0 | h | ~3 | h | elimination half-life; intravenous infusion, IV in drop; | DRUGBANK |
| Toxicity LD50 | 50.0 | mg/kg | 50.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 100.0 | mg/kg | 100.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 50.0 | mg/kg | 50.0 | mg/kg | PO, oral; mouse; | T3DB | Toxicity LD50 | 100.0 | mg/kg | 100.0 | mg/kg | PO, oral; Rattus, Rat; | T3DB |
| Eliminate Route | 74.0 | % | 74 | % | Urinary excretion; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 3.0 | drop/day | 3 | drop/day | ophthalmic administration | Brimonidine Tartrate | brimonidine tartrate | PDR |
| Max dose for children | 4.0 | drop/day | 4 | drop/day | ophthalmic administration | Brimonidine Tartrate | brimonidine tartrate | PDR |
| Max dose for children | 3.0 | drop/day | 3 | drop/day | ophthalmic administration | Brimonidine Tartrate | brimonidine tartrate | PDR |
| Max dose for adolescents | 3.0 | drop/day | 3 | drop/day | ophthalmic administration | Brimonidine Tartrate | brimonidine tartrate | PDR |
| Max dose for adolescents | 4.0 | drop/day | 4 | drop/day | ophthalmic administration | Brimonidine Tartrate | brimonidine tartrate | PDR |
| Max dose for adults | 3.0 | drop/day | 3 | drop/day | ophthalmic administration | Brimonidine Tartrate | brimonidine tartrate | PDR |
| Max dose for adults | 4.0 | drop/day | 4 | drop/day | ophthalmic administration | Brimonidine Tartrate | brimonidine tartrate | PDR |
| Max dose for adults | 1.0 | appLication/day | 1 | appLication/day | skin/dermal | Brimonidine Tartrate | brimonidine tartrate | PDR |
| Max dose for geriatric | 3.0 | drop/day | 3 | drop/day | ophthalmic administration | Brimonidine Tartrate | brimonidine tartrate | PDR |
| Max dose for geriatric | 4.0 | drop/day | 4 | drop/day | ophthalmic administration | Brimonidine Tartrate | brimonidine tartrate | PDR |
| Max dose for geriatric | 1.0 | application/day | 1 | application/day | skin/dermal | Brimonidine Tartrate | brimonidine tartrate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1