Basic Information
| Drug ID | DDPD00478 |
|
| Drug Name | Rimantadine | |
| Molecular Weight | 179.3018 | |
| Molecular Formula | C12H21N | |
| CAS Number | 13392-28-4 | |
| SMILES | CC(N)C12CC3CC(CC(C3)C1)C2 | |
| External Links | ||
| DRUGBANK | DB00478 | |
| PubChem Compound | 5071 | |
| PDR | 2894 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.6 | - | 3.6 | - | DRUGBANK |
| Melting Point | 300.0 | ℃ | >300 | ℃ | DRUGBANK |
| Water Solubility | 50000.0 | mg/L | 50 | mg/ml | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Metabolic | 25.0 | % | <25 | % | Urinary excretion; Unchanged drug; PO, oral; | DRUGBANK |
| Half-life | 27.5 | h | 25-30 | h | young; adults; | DRUGBANK | Half-life | 32.0 | h | ~32 | h | Elderly; | DRUGBANK | Half-life | 32.0 | h | ~32 | h | chronic liver disease; patients; | DRUGBANK | Half-life | 25.5 | h | ~13-38 | h | Children; | DRUGBANK |
| Toxicity LD50 | 640.0 | mg/kg | 640.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Eliminate Route | 25.0 | % | <25 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 200.0 | mg/day | 200 | mg/day | PO, oral | Flumadine | rimantadine hydrochloride | PDR |
| Max dose for children | 5.0 | mg/kg/day | 5 | mg/kg/day | PO, oral | Flumadine | rimantadine hydrochloride | PDR |
| Max dose for children | 150.0 | mg/day | 150 | mg/day | PO, oral | Flumadine | rimantadine hydrochloride | PDR |
| Max dose for adolescents | 200.0 | mg/day | 200 | mg/day | PO, oral | Flumadine | rimantadine hydrochloride | PDR |
| Max dose for adults | 200.0 | mg/day | 200 | mg/day | PO, oral | Flumadine | rimantadine hydrochloride | PDR |
| Max dose for geriatric | 200.0 | mg/day | 200 | mg/day | PO, oral | Flumadine | rimantadine hydrochloride | PDR |
| Max dose for geriatric | 100.0 | mg/day | 100 | mg/day | PO, oral | Flumadine | rimantadine hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1