Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00470 ...
Drug Name Dronabinol
Molecular Weight 314.4617
Molecular Formula C21H30O2
CAS Number 1972-08-3
SMILES [H][C@@]12C=C(C)CC[C@@]1([H])C(C)(C)OC1=C2C(O)=CC(CCCCC)=C1
External Links
DRUGBANK DB00470
T3DB T3D2801
PubChem Compound 16078
PDR 2726

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 5.648 - 5.648 - DRUGBANK
Melting Point 200.0 ℃ 200 ℃ DRUGBANK
Water Solubility 2800.0 mg/L 2800 mg/L NIH NTP Reports web-site
pKa 10.6 - 10.6 - PHYSICIAN'S DESK REFERENCE (1998)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Absorption 92.5 % 90-95 % Oral single dose; DRUGBANK
Bioavailability 15.0 % 10-20 % Oral single dose; DRUGBANK
C Max 1.3 ng/ml 1.32 ng/ml Oral single dose; DRUGBANK
T Max 3.0 h 2-4 h Oral single dose; DRUGBANK
T Max 1.0 h 1 h Oral single dose; DRUGBANK
Clearance 0.20 L/h/kg 0.2 L/h/kg Average clearance; DRUGBANK
Volume of Distribution 10.0 L/kg 10.0 L/kg Apparent volume of distribution; DRUGBANK
Half-life 4.0 h 4 h elimination half-life; DRUGBANK
Half-life 30.5 h 25-36 h terminal half-life; DRUGBANK
Protein Binding 97.0 % ~97 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for adults 60.0 mg/m2/day 15 mg/m2/dose PO, oral q6h-q4h Marinol dronabinol PDR
Max dose for adults 50.4 mg/m2/day 12.6 mg/m2/dose PO, oral q6h-q4h Marinol dronabinol PDR
Max dose for adults 10.0 mg 10 mg PO, oral bid Marinol dronabinol PDR
Max dose for adults 16.8 mg/day 16.8 mg/day PO, oral Marinol dronabinol PDR
Max dose for geriatric 15.0 mg/m2/dose 15 mg/m2/dose Capsule, PO, Oral q6h-q4h Marinol dronabinol PDR
Max dose for geriatric 12.6 mg/m2/dose 12.6 mg/m2/dose Liquid q6h-q4h Marinol dronabinol PDR
Max dose for geriatric 10.0 mg 10 mg Capsule, PO, Oral bid Marinol dronabinol PDR
Max dose for geriatric 16.8 mg/day 16.8 mg/day Liquid Marinol dronabinol PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1