Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00468 ...
Drug Name Quinine
Molecular Weight 324.4168
Molecular Formula C20H24N2O2
CAS Number 130-95-0
SMILES [H][C@]1(C[C@@H]2CC[N@]1C[C@@H]2C=C)[C@H](O)C1=CC=NC2=CC=C(OC)C=C12
External Links
DRUGBANK DB00468
T3DB T3D2800
PubChem Compound 3034034
PDR 828
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.44 - 3.44 - HANSCH,C ET AL. (1995)
Melting Point 57.0 ℃ 57 ℃ PhysProp
Water Solubility 500.0 mg/L 500 mg/L YALKOWSKY,SH & DANNENFELSER,RM 1992)
Log S -2.76 - -2.76 - ADME Research, USCD

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 82.0 % 76-88 % DRUGBANK
Bioavailability 76.0 % 76±11 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 11000.0 ng/ml 11±2 mcg/ml intravenous injection, IV; adults; malaria; The Pharmacological Basis of Therapeutics
C Max 8350.0 ng/ml 7.3-9.4 mcg/ml PO, oral; adults; malaria; The Pharmacological Basis of Therapeutics
C Max 9050.0 ng/ml 8.7-9.4 mcg/ml intravenous injection, IV; Children; malaria; The Pharmacological Basis of Therapeutics
C Max 7300.0 ng/ml 7.3±1.1 mcg/ml PO, oral; Children; malaria; The Pharmacological Basis of Therapeutics
T Max 6.0 h 3.5-8.4 h PO, oral; Children; adults; malaria; The Pharmacological Basis of Therapeutics
Metabolic 80.0 % 80 % Liver metabolism; DRUGBANK
Clearance 0.0700 L/h/kg 0.07 L/h/kg normal,healthy; DRUGBANK
Clearance 0.19 L/h/kg 0.19 L/h/kg malaria; patients; DRUGBANK
Clearance 18.4 L/h 18.4 L/h normal,healthy; adults; increasing doses; DRUGBANK
Clearance 11.8 L/h 11.8 L/h normal,healthy; adults; DRUGBANK
Clearance 0.0600 L/h/kg 0.06 L/h/kg Total clearance; PO, oral; Elderly; DRUGBANK
Clearance 0.11 L/h/kg 1.9±0.5 ml/min/kg normal,healthy; adults; The Pharmacological Basis of Therapeutics
Clearance 0.0690 L/h/kg 0.9-1.4 ml/min/kg malaria; adults; The Pharmacological Basis of Therapeutics
Clearance 0.0540 L/h/kg 0.4-1.4 ml/min/kg malaria; Children; Elderly ↓ ;Preg, pregnant → ;RD, renal impairment, Renal disease，including uremia → ;Somking ↑ ; The Pharmacological Basis of Therapeutics
Clearance 0.11 L/h/kg 1.9 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 1.4 L/kg 1.43±0.18 L/kg normal,healthy; Children; DRUGBANK
Volume of Distribution 0.87 L/kg 0.87±0.12 L/kg malaria; pediatric patients; DRUGBANK
Volume of Distribution 4.8 L/kg 2.5-7.1 L/kg Oral single dose; normal,healthy; DRUGBANK
Volume of Distribution 1.8 L/kg 1.8±0.4 L/kg normal,healthy; adults; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.4 L/kg 1.0-1.7 L/kg malaria; adults; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.5 L/kg 1.2-1.7 L/kg malaria; Children; Preg, pregnant ↓ ;RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.8 L/kg 1.8 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 18.0 h ~18 h DRUGBANK
Half-life 11.0 h 11±2 h normal,healthy; adults; Hepatitis, Hep ↑ ;Somking ↓ ;Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 14.5 h 11-18 h malaria; adults; Preg, pregnant ↓ ;RD, renal impairment, Renal disease，including uremia → ;Hepatitis, Hep ↑ ;Somking ↓ ;Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 14.0 h 12-16 h malaria; Children; Hepatitis, Hep ↑ ;Somking ↓ ;Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 11.0 h 11 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 20.0 % ~20 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 16.0 % 12-20 % Urinary excretion; adults; normal,healthy; Unchanged drug; The Pharmacological Basis of Therapeutics
Eliminate Route 33.0 % 33±18 % Urinary excretion; adults; malaria; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 70.0 % ~70 % DRUGBANK
Protein Binding 87.5 % ~85-90 % adults; normal,healthy; human, homo sapiens; Neonates ↓ ;Preg, pregnant → ; The Pharmacological Basis of Therapeutics
Protein Binding 94.0 % 93-95 % adults; malaria; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 30.0 mg/kg/day 30 mg/kg/day PO, oral Qualaquin quinine sulfate PDR
Max dose for children 1944.0 mg/day 1944 mg/day PO, oral Qualaquin quinine sulfate PDR
Max dose for adolescents 1944.0 mg/day 1944 mg/day PO, oral Qualaquin quinine sulfate PDR
Max dose for adolescents 30.0 mg/kg/day 30 mg/kg/day PO, oral Qualaquin quinine sulfate PDR
Max dose for adolescents 1944.0 mg/day 1944 mg/day PO, oral Qualaquin quinine sulfate PDR
Max dose for adults 1944.0 mg/day 1944 mg/day PO, oral Qualaquin quinine sulfate PDR
Max dose for geriatric 1944.0 mg/day 1944 mg/day PO, oral Qualaquin quinine sulfate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1