Basic Information
| Drug ID | DDPD00465 |
|
| Drug Name | Ketorolac | |
| Molecular Weight | 255.2686 | |
| Molecular Formula | C15H13NO3 | |
| CAS Number | 74103-06-3 | |
| SMILES | OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 | |
| External Links | ||
| DRUGBANK | DB00465 | |
| PubChem Compound | 3826 | |
| PDR | 1107 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.1 | - | 2.1 | - | DRUGBANK |
| Melting Point | 163.5 | ℃ | 162-165 | ℃ | Ketorolac tromethamine MSDS |
| Water Solubility | 200000.0 | mg/L | 200 | g/l | Ketorolac thromethamine MSDS |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Absorption | 100.0 | % | 100.0 | % | PO, oral; | DRUGBANK | |
| Bioavailability | 80.0 | % | 80.0 | % | PO, oral; | DRUGBANK | Bioavailability | 100.0 | % | 100±20 | % | PO, oral; | The Pharmacological Basis of Therapeutics |
| C Max | 2600.0 | ng/ml | 2.2-3.0 | mcg/ml | IM,intramuscular injection; adults; normal,healthy; | The Pharmacological Basis of Therapeutics | C Max | 850.0 | ng/ml | 0.8-0.9 | mcg/ml | PO, oral; adults; normal,healthy; | The Pharmacological Basis of Therapeutics |
| T Max | 0.67 | h | 0.33-1 | h | PO, oral; | DRUGBANK | T Max | 0.75 | h | 0.67-0.83 | h | IM,intramuscular injection; | DRUGBANK | T Max | 0.75 | h | 0.7-0.8 | h | IM,intramuscular injection; adults; normal,healthy; | The Pharmacological Basis of Therapeutics | T Max | 0.60 | h | 0.3-0.9 | h | PO, oral; adults; normal,healthy; | The Pharmacological Basis of Therapeutics |
| Clearance | 0.0290 | L/h/kg | 0.021-0.037 | L/h/kg | DRUGBANK | Clearance | 0.0300 | L/h/kg | 0.50±0.15 | ml/min/kg | Elderly ↓ ;Hepatic cirrhosis, cirr → ;RD, renal impairment, Renal disease，including uremia ↓ ; | The Pharmacological Basis of Therapeutics | Clearance | 0.0210 | L/h/kg | 0.35 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.25 | L/kg | 0.25 | L/kg | Apparent volume of distribution; | DRUGBANK | Volume of Distribution | 0.50 | L/kg | 0.50±0.15 | L/kg | The Pharmacological Basis of Therapeutics | Volume of Distribution | 0.11 | L/kg | 0.11 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 2.5 | h | ~2.5 | h | Optical rotation S; | DRUGBANK | Half-life | 5.0 | h | ~5 | h | Optical rotation R; | DRUGBANK | Half-life | 5.3 | h | 5.3±1.2 | h | RD, renal impairment, Renal disease，including uremia ↑ ;Hepatic cirrhosis, cirr → ;Age ↑ ; | The Pharmacological Basis of Therapeutics | Half-life | 5.1 | h | 5.1 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 55.2 | % | 55.2 | % | Urinary excretion; Unchanged drug; | DRUGBANK | Eliminate Route | 7.5 | % | 5-10 | % | Urinary excretion; Raceme D/L; Unchanged drug; | The Pharmacological Basis of Therapeutics |
| Protein Binding | 99.0 | % | >99 | % | plasma proteins; | DRUGBANK | Protein Binding | 99.2 | % | 99.2±0.1 | % | Raceme D/L; | The Pharmacological Basis of Therapeutics |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 0.5 | mg/kg/dose | 0.5 | mg/kg/dose | intravenous injection, IV | Acular | ketorolac tromethamine | PDR |
| Max dose for neonates | 1.0 | mg/kg/dose | 1 | mg/kg/dose | IM,intramuscular injection | Acular | ketorolac tromethamine | PDR |
| Max dose for neonates | 2.0 | mg/kg/day | 0.5 | mg/kg/dose | intravenous injection, IV;IM,intramuscular injection; | Acular | ketorolac tromethamine | PDR |
| Max dose for neonates | 2.0 | mg/kg/day | 0.5 | mg/kg/dose | intravenous injection, IV | Acular | ketorolac tromethamine | PDR |
| Max dose for infants | 0.5 | mg/kg/dose | 0.5 | mg/kg/dose | intravenous injection, IV | Acular | ketorolac tromethamine | PDR |
| Max dose for infants | 15.0 | mg/dose | 15 | mg/dose | intravenous injection, IV | Acular | ketorolac tromethamine | PDR |
| Max dose for infants | 1.0 | mg/kg/dose | 1 | mg/kg/dose | IM,intramuscular injection | Acular | ketorolac tromethamine | PDR |
| Max dose for infants | 30.0 | mg/dose | 30 | mg/dose | IM,intramuscular injection | Acular | ketorolac tromethamine | PDR |
| Max dose for infants | 2.0 | mg/kg/day | 0.5 | mg/kg/dose | intravenous injection, IV;IM,intramuscular injection; | Acular | ketorolac tromethamine | PDR |
| Max dose for infants | 120.0 | mg/day | 30 | mg/dose | intravenous injection, IV;IM,intramuscular injection; | Acular | ketorolac tromethamine | PDR |
| Max dose for infants | 1.0 | mg/kg/day | 0.25 | mg/kg/dose | PO, oral | Acular | ketorolac tromethamine | PDR |
| Max dose for infants | 40.0 | mg/day | 10 | mg/dose | PO, oral | Acular | ketorolac tromethamine | PDR |
| Max dose for infants | 0.5 | mg/kg/dose | 0.5 | mg/kg/dose | intravenous injection, IV | Acular | ketorolac tromethamine | PDR |
| Max dose for infants | 1.0 | mg/kg/dose | 1 | mg/kg/dose | IM,intramuscular injection | Acular | ketorolac tromethamine | PDR |
| Max dose for infants | 2.0 | mg/kg/day | 0.5 | mg/kg/dose | intravenous injection, IV;IM,intramuscular injection; | Acular | ketorolac tromethamine | PDR |
| Max dose for infants | 120.0 | mg/day | 30 | mg/dose | intravenous injection, IV;IM,intramuscular injection; | Acular | ketorolac tromethamine | PDR |
| Max dose for infants | 1.0 | mg/kg/day | 0.25 | mg/kg/dose | PO, oral | Acular | ketorolac tromethamine | PDR |
| Max dose for infants | 40.0 | mg/day | 10 | mg/dose | PO, oral | Acular | ketorolac tromethamine | PDR |
| Max dose for children | 30.0 | mg | 30 | mg | intravenous injection, IV | Acular | ketorolac tromethamine | PDR |
| Max dose for children | 60.0 | mg | 60 | mg | IM,intramuscular injection | Acular | ketorolac tromethamine | PDR |
| Max dose for children | 120.0 | mg/day | 120 | mg/day | intravenous injection, IV;IM,intramuscular injection; | Acular | ketorolac tromethamine | PDR |
| Max dose for children | 40.0 | mg/day | 40 | mg/day | PO, oral | Acular | ketorolac tromethamine | PDR |
| Max dose for children | 15.0 | mg | 15 | mg | intravenous injection, IV | Acular | ketorolac tromethamine | PDR |
| Max dose for children | 30.0 | mg | 30 | mg | IM,intramuscular injection | Acular | ketorolac tromethamine | PDR |
| Max dose for children | 60.0 | mg/day | 60 | mg/day | intravenous injection, IV;IM,intramuscular injection; | Acular | ketorolac tromethamine | PDR |
| Max dose for children | 40.0 | mg/day | 40 | mg/day | PO, oral | Acular | ketorolac tromethamine | PDR |
| Max dose for children | 0.5 | mg/kg/dose | 0.5 | mg/kg/dose | intravenous injection, IV | Acular | ketorolac tromethamine | PDR |
| Max dose for children | 15.0 | mg/dose | 15 | mg/dose | intravenous injection, IV | Acular | ketorolac tromethamine | PDR |
| Max dose for children | 1.0 | mg/kg/dose | 1 | mg/kg/dose | IM,intramuscular injection | Acular | ketorolac tromethamine | PDR |
| Max dose for children | 30.0 | mg/dose | 30 | mg/dose | IM,intramuscular injection | Acular | ketorolac tromethamine | PDR |
| Max dose for children | 1.5 | mg/kg/day | 0.5 | mg/kg/dose | intravenous injection, IV;IM,intramuscular injection; | Acular | ketorolac tromethamine | PDR |
| Max dose for children | 30.0 | mg/dose | 30 | mg/dose | intravenous injection, IV;IM,intramuscular injection; | Acular | ketorolac tromethamine | PDR |
| Max dose for children | 0.75 | mg/kg/day | 0.25 | mg/kg/dose | PO, oral | Acular | ketorolac tromethamine | PDR |
| Max dose for children | 10.0 | mg/dose | 10 | mg/dose | PO, oral | Acular | ketorolac tromethamine | PDR |
| Max dose for adolescents | 15.0 | mg/dose | 15 | mg/dose | intravenous injection, IV | Acular | ketorolac tromethamine | PDR |
| Max dose for adolescents | 30.0 | mg/dose | 30 | mg/dose | IM,intramuscular injection | Acular | ketorolac tromethamine | PDR |
| Max dose for adolescents | 60.0 | mg/day | 60 | mg/day | intravenous injection, IV;IM,intramuscular injection; | Acular | ketorolac tromethamine | PDR |
| Max dose for adolescents | 40.0 | mg/day | 40 | mg/day | PO, oral | Acular | ketorolac tromethamine | PDR |
| Max dose for adolescents | 63.0 | mg/day | 63 | mg/day | intranasal | Acular | ketorolac tromethamine | PDR |
| Max dose for geriatric | 30.0 | mg/dose | 30 | mg/dose | intravenous injection, IV | Acular | ketorolac tromethamine | PDR |
| Max dose for geriatric | 60.0 | mg/dose | 60 | mg/dose | IM,intramuscular injection | Acular | ketorolac tromethamine | PDR |
| Max dose for geriatric | 120.0 | mg/day | 120 | mg/day | intravenous injection, IV;IM,intramuscular injection; | Acular | ketorolac tromethamine | PDR |
| Max dose for geriatric | 40.0 | mg/day | 40 | mg/day | PO, oral | Acular | ketorolac tromethamine | PDR |
| Max dose for geriatric | 126.0 | mg/day | 126 | mg/day | intranasal | Acular | ketorolac tromethamine | PDR |
| Max dose for geriatric | 15.0 | mg/dose | 15 | mg/dose | intravenous injection, IV | Acular | ketorolac tromethamine | PDR |
| Max dose for geriatric | 30.0 | mg/dose | 30 | mg/dose | IM,intramuscular injection | Acular | ketorolac tromethamine | PDR |
| Max dose for geriatric | 60.0 | mg/day | 60 | mg/day | intravenous injection, IV;IM,intramuscular injection; | Acular | ketorolac tromethamine | PDR |
| Max dose for geriatric | 40.0 | mg/day | 40 | mg/day | PO, oral | Acular | ketorolac tromethamine | PDR |
| Max dose for geriatric | 63.0 | mg/day | 63 | mg/day | intranasal | Acular | ketorolac tromethamine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1