Basic Information
| Drug ID | DDPD00459 |
|
| Drug Name | Acitretin | |
| Molecular Weight | 326.4293 | |
| Molecular Formula | C21H26O3 | |
| CAS Number | 55079-83-9 | |
| SMILES | COC1=C(C)C(C)=C(\C=C\C(\C)=C\C=C\C(\C)=C\C(O)=O)C(C)=C1 | |
| External Links | ||
| DRUGBANK | DB00459 | |
| PubChem Compound | 5284513 | |
| PDR | 547 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 6.4 | - | 6.4 | - | SANGSTER (1993) |
| Melting Point | 229.0 | ℃ | 228-230 | ℃ | PhysProp |
| Water Solubility | 0.0729 | mg/L | 0.0729 | mg/L | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 72.0 | % | 72(47-109) | % | Oral single dose; | DRUGBANK |
| Half-life | 49.0 | h | 49(33-96) | h | DRUGBANK | |
| Toxicity LD50 | 4000.0 | mg/kg | >4000 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Eliminate Route | 34.5 | % | 16-53 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 44.0 | % | 34-54 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 99.9 | % | >99.9 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 50.0 | mg/day | 50 | mg/day | PO, oral | Soriatane | acitretin | PDR |
| Max dose for elderly | 50.0 | mg/day | 50 | mg/day | PO, oral | Soriatane | acitretin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1