Basic Information
| Drug ID | DDPD00454 |
|
| Drug Name | Meperidine | |
| Molecular Weight | 247.3327 | |
| Molecular Formula | C15H21NO2 | |
| CAS Number | 57-42-1 | |
| SMILES | CCOC(=O)C1(CCN(C)CC1)C1=CC=CC=C1 | |
| External Links | ||
| DRUGBANK | DB00454 | |
| T3DB | T3D2795 | |
| PubChem Compound | 4058 | |
| PDR | 1146 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.72 | - | 2.72 | - | SANGSTER (1994) |
| Melting Point | 270.0 | ℃ | 270 | ℃ | PhysProp |
| Water Solubility | 3220.0 | mg/L | 3220 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| pKa | 8.59 | - | 8.59 | - | SANGSTER (1994) |
| Log S | -1.89 | - | -1.89 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Bioavailability | 55.0 | % | 50-60 | % | PO, oral; | DRUGBANK | Bioavailability | 85.0 | % | 80-90 | % | PO, oral; Hepatitis, Hep; | Hepatitis, Hep ↑ ; | DRUGBANK | Bioavailability | 27.5 | % | 25-30 | % | parenteral administration; | DRUGBANK | Bioavailability | 82.5 | % | 80-85 | % | IM,intramuscular injection; normal,healthy; adults; | DRUGBANK | Bioavailability | 52.0 | % | 52±3 | % | PO, oral; | The Pharmacological Basis of Therapeutics |
| C Max | 700.0 | ng/ml | ~0.7 | mcg/ml | PO, oral; | The Pharmacological Basis of Therapeutics | C Max | 670.0 | ng/ml | 0.67 | mcg/ml | intravenous injection, IV; | The Pharmacological Basis of Therapeutics |
| T Max | 1.0 | h | <1 | h | PO, oral; | The Pharmacological Basis of Therapeutics | |
| Clearance | 1.0 | L/h/kg | 17±5 | ml/min/kg | Neonates ↓ ;Prem, premature ↓ ;Elderly → ;Preg, pregnant → ;acute viral hepatitis AVH ↓ ;Hepatic cirrhosis, cirr ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ;Somking → ; | The Pharmacological Basis of Therapeutics | Clearance | 0.29 | L/h/kg | 4.9 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 4.4 | L/kg | 4.4±0.9 | L/kg | Elderly ↑ ;Preg, pregnant → ;Prem, premature ↑ ;Hepatic cirrhosis, cirr → ;RD, renal impairment, Renal disease，including uremia → ; | The Pharmacological Basis of Therapeutics | Volume of Distribution | 2.3 | L/kg | 2.3 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 0.11 | h | 2-11 | min | distribution half-life; | DRUGBANK | Half-life | 4.0 | h | 3-5 | h | elimination half-life; | DRUGBANK | Half-life | 9.0 | h | 7-11 | h | hepatopathy，LD; patients; | DRUGBANK | Half-life | 3.2 | h | 3.2±0.8 | h | Prem, premature ↑ ;Neonates ↑ ;Preg, pregnant → ;acute viral hepatitis AVH ↑ ;Hepatic cirrhosis, cirr ↑ ;RD, renal impairment, Renal disease，including uremia ↑ ;Age ↑ ; | The Pharmacological Basis of Therapeutics | Half-life | 7.9 | h | 7.9 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 5.0 | % | ~5 | % | Urinary excretion; Unchanged drug; | DRUGBANK | Eliminate Route | 5.0 | % | ~5(1-25) | % | Urinary excretion; Unchanged drug; | The Pharmacological Basis of Therapeutics |
| Protein Binding | 70.0 | % | 60-80 | % | plasma proteins; | DRUGBANK | Protein Binding | 58.0 | % | 58±9 | % | Elderly ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ;Hepatic cirrhosis, cirr → ; | The Pharmacological Basis of Therapeutics |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 1.8 | mg/kg/dose | 1.8 | mg/kg/dose | PO, oral;intravenous injection, IV;IM,intramuscular injection;subcutaneous injection, SC; | Meperidine Hydrochloride Injection Solution | meperidine hydrochloride | PDR |
| Max dose for children | 150.0 | mg/dose | 150 | mg/dose | PO, oral;intravenous injection, IV;IM,intramuscular injection;subcutaneous injection, SC; | Meperidine Hydrochloride Injection Solution | meperidine hydrochloride | PDR |
| Max dose for children | 2.2 | mg/kg/dose | 2.2 | mg/kg/dose | IM,intramuscular injection;subcutaneous injection, SC; | Meperidine Hydrochloride Injection Solution | meperidine hydrochloride | PDR |
| Max dose for children | 100.0 | mg/kg/dose | 100 | mg/kg/dose | IM,intramuscular injection;subcutaneous injection, SC; | Meperidine Hydrochloride Injection Solution | meperidine hydrochloride | PDR |
| Max dose for adolescents | 1.8 | mg/kg/dose | 1.8 | mg/kg/dose | PO, oral;intravenous injection, IV;IM,intramuscular injection;subcutaneous injection, SC; | Meperidine Hydrochloride Injection Solution | meperidine hydrochloride | PDR |
| Max dose for adolescents | 150.0 | mg/dose | 150 | mg/dose | PO, oral;intravenous injection, IV;IM,intramuscular injection;subcutaneous injection, SC; | Meperidine Hydrochloride Injection Solution | meperidine hydrochloride | PDR |
| Max dose for adolescents | 2.2 | mg/kg/dose | 2.2 | mg/kg/dose | IM,intramuscular injection;subcutaneous injection, SC; | Meperidine Hydrochloride Injection Solution | meperidine hydrochloride | PDR |
| Max dose for adolescents | 100.0 | mg/kg/dose | 100 | mg/kg/dose | IM,intramuscular injection;subcutaneous injection, SC; | Meperidine Hydrochloride Injection Solution | meperidine hydrochloride | PDR |
| Max dose for adults | 150.0 | mg/dose | 150 | mg/dose | PO, oral;intravenous injection, IV;IM,intramuscular injection;subcutaneous injection, SC; | Meperidine Hydrochloride Injection Solution | meperidine hydrochloride | PDR |
| Max dose for adults | 100.0 | mg/dose | 100 | mg/dose | IM,intramuscular injection;subcutaneous injection, SC; | Meperidine Hydrochloride Injection Solution | meperidine hydrochloride | PDR |
| Max dose for geriatric | 150.0 | mg/dose | 150 | mg/dose | PO, oral;intravenous injection, IV;IM,intramuscular injection;subcutaneous injection, SC; | Meperidine Hydrochloride Injection Solution | meperidine hydrochloride | PDR |
| Max dose for geriatric | 100.0 | mg/dose | 100 | mg/dose | IM,intramuscular injection;subcutaneous injection, SC; | Meperidine Hydrochloride Injection Solution | meperidine hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1