Basic Information
| Drug ID | DDPD00451 |
|
| Drug Name | Levothyroxine | |
| Molecular Weight | 776.87 | |
| Molecular Formula | C15H11I4NO4 | |
| CAS Number | 51-48-9 | |
| SMILES | N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O)=O | |
| External Links | ||
| DRUGBANK | DB00451 | |
| PubChem Compound | 5819 | |
| PDR | 1177 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 4.0 | - | 4.0 | - | DRUGBANK |
| Melting Point | 235.5 | ℃ | 235.5 | ℃ | PhysProp |
| Water Solubility | 105.0 | mg/L | 0.105 | mg/ml | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Absorption | 60.0 | % | 40-80 | % | PO, oral; | DRUGBANK | |
| Half-life | 156.0 | h | 6-7 | day | DRUGBANK | Half-life | 36.0 | h | 1-2 | day | DRUGBANK |
| Toxicity LD50 | 20.0 | mg/kg | 20.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | |
| Eliminate Route | 20.0 | % | 20 | % | Faeces excretion; | Age ↓ ; | DRUGBANK |
| Protein Binding | 99.0 | % | >99 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 0.1 | mg/day | 100 | mcg/day | PO, oral | Thyrolar | liotrix (T3;T4) | PDR |
| Max dose for children | 0.025 | mg/day | 25 | mcg/day | PO, oral | Thyrolar | liotrix (T3;T4) | PDR |
| Max dose for adolescents | 0.1 | mg/day | 100 | mcg/day | PO, oral | Thyrolar | liotrix (T3;T4) | PDR |
| Max dose for adolescents | 0.025 | mg/day | 25 | mcg/day | PO, oral | Thyrolar | liotrix (T3;T4) | PDR |
| Max dose for elderly | 0.1 | mg/day | 100 | mcg/day | PO, oral | Thyrolar | liotrix (T3;T4) | PDR |
| Max dose for elderly | 0.025 | mg/day | 25 | mcg/day | PO, oral | Thyrolar | liotrix (T3;T4) | PDR |
| Max dose for children | 0.2 | mg/day | 200 | mcg/day | PO, oral | Tirosint | levothyroxine sodium | PDR |
| Max dose for children | 0.3 | mg/day | 300 | mcg/day | PO, oral | Tirosint | levothyroxine sodium | PDR |
| Max dose for adolescents | 0.2 | mg/day | 200 | mcg/day | PO, oral | Tirosint | levothyroxine sodium | PDR |
| Max dose for adolescents | 0.3 | mg/day | 300 | mcg/day | PO, oral | Tirosint | levothyroxine sodium | PDR |
| Max dose for geriatric | 0.2 | mg/day | 200 | mcg/day | PO, oral | Tirosint | levothyroxine sodium | PDR |
| Max dose for geriatric | 0.3 | mg/day | 300 | mcg/day | PO, oral | Tirosint | levothyroxine sodium | PDR |
| Max dose for children | 120.0 | mg/day | 120 | mg/day | PO, oral | Armour Thyroid | thyroid | PDR |
| Max dose for adolescents | 120.0 | mg/day | 120 | mg/day | PO, oral | Armour Thyroid | thyroid | PDR |
| Max dose for geriatric | 120.0 | mg/day | 120 | mg/day | PO, oral | Armour Thyroid | thyroid | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1