Basic Information
| Drug ID | DDPD00450 |
|
| Drug Name | Droperidol | |
| Molecular Weight | 379.4274 | |
| Molecular Formula | C22H22FN3O2 | |
| CAS Number | 548-73-2 | |
| SMILES | FC1=CC=C(C=C1)C(=O)CCCN1CCC(=CC1)N1C(=O)NC2=CC=CC=C12 | |
| External Links | ||
| DRUGBANK | DB00450 | |
| PubChem Compound | 3168 | |
| PDR | 1412 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.5 | - | 3.5 | - | SANGSTER (1993) |
| Melting Point | 145.75 | ℃ | 145-146.5 | ℃ | Janssen, P.A.J. and Gardocki, J.F.; U.S. Patent 3,141,823; July 21, 1964; assigned to Research Laboratorium Dr. C. Janssen NV, Belgium. Januen, P.A.J.; U.S. Patent 3,161,645; December 15,1964: assigned to Research Laboratorium Dr. C. Janssen NV, Belgium. |
| Water Solubility | 4.21 | mg/L | 4.21 | mg/L | DRUGBANK |
| pKa | 7.46 | - | 7.46 | - | SANGSTER (1994) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Absorption | 100.0 | % | 100.0 | % | IM,intramuscular injection; | DRUGBANK | |
| Clearance | 0.54 | L/h/kg | 8.92 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset | |
| Volume of Distribution | 1.4 | L/kg | 1.41 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset | |
| Half-life | 0.0233 | h | 1.4±0.5 | min | rapid distribution half-life; | DRUGBANK | Half-life | 0.24 | h | 14.3±6.5 | min | rapid distribution half-life; | DRUGBANK | Half-life | 2.2 | h | 134±13 | min | elimination half-life; adults; | patients ↑ ; | DRUGBANK | Half-life | 1.7 | h | 101.5±26.4 | min | Children; | DRUGBANK | Half-life | 1.9 | h | 1.9 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 31.5 | mg/kg | 20-43 | mg/kg | intravenous injection, IV; mouse; | DRUGBANK | Toxicity LD50 | 30.0 | mg/kg | 30.0 | mg/kg | intravenous injection, IV; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 25.0 | mg/kg | 25.0 | mg/kg | intravenous injection, IV; dog; | DRUGBANK | Toxicity LD50 | 12.0 | mg/kg | 11-13 | mg/kg | intravenous injection, IV; rabbit; | DRUGBANK | Toxicity LD50 | 195.0 | mg/kg | 195 | mg/kg | IM,intramuscular injection; mouse; | DRUGBANK | Toxicity LD50 | 107.0 | mg/kg | 104-110 | mg/kg | IM,intramuscular injection; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 97.0 | mg/kg | 97 | mg/kg | IM,intramuscular injection; rabbit; | DRUGBANK | Toxicity LD50 | 200.0 | mg/kg | 200 | mg/kg | IM,intramuscular injection; guinea pigs; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 0.1 | mg/kg | 0.1 | mg/kg | intravenous injection, IV;IM,intramuscular injection; | Droperidol | droperidol | PDR |
| Max dose for adolescents | 2.5 | mg/dose | 2.5 | mg/dose | intravenous injection, IV;IM,intramuscular injection; | Droperidol | droperidol | PDR |
| Max dose for adults | 2.5 | mg/dose | 2.5 | mg/dose | intravenous injection, IV;IM,intramuscular injection; | Droperidol | droperidol | PDR |
| Max dose for elderly | 2.5 | mg/dose | 2.5 | mg/dose | intravenous injection, IV;IM,intramuscular injection; | Droperidol | droperidol | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1