Basic Information

Drug ID DDPD00445 ...
Drug Name Epirubicin
Molecular Weight 543.5193
Molecular Formula C27H29NO11
CAS Number 56420-45-2
SMILES COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3O[C@H]3C[C@H](N)[C@@H](O)[C@H](C)O3)C(=O)CO)C(O)=C1C2=O
External Links
DRUGBANK DB00445
T3DB T3D2791
PubChem Compound 41867
PDR 2404
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -0.5 - -0.5 - DRUGBANK
Melting Point 344.53 344.53 DRUGBANK
Water Solubility 93.0 mg/L 0.093 mg/ml DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Absorption 100.0 % 100.0 % DRUGBANK
Clearance 65.0 L/h 65±8 L/h intravenous injection, IV; tumor; patients; DRUGBANK
Clearance 83.0 L/h 83±14 L/h intravenous injection, IV; tumor; patients; DRUGBANK
Clearance 65.0 L/h 65±13 L/h intravenous injection, IV; tumor; patients; DRUGBANK
Clearance 69.0 L/h 69±13 L/h intravenous injection, IV; tumor; patients; DRUGBANK
Clearance 1.2 L/h/kg 20 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 21.0 L/kg 21±2 L/kg DRUGBANK
Volume of Distribution 27.0 L/kg 27±11 L/kg DRUGBANK
Volume of Distribution 23.0 L/kg 23±7 L/kg DRUGBANK
Volume of Distribution 21.0 L/kg 21±7 L/kg DRUGBANK
Volume of Distribution 45.0 L/kg 45 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 0.0500 h 3 min distribution half-life; DRUGBANK
Half-life 2.5 h 2.5 h elimination half-life; DRUGBANK
Half-life 33.0 h 33 h terminal half-life; DRUGBANK
Half-life 36.0 h 36 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Protein Binding 77.0 % 77 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 120.0 mg/m2/dose 120 mg/m2/dose Ellence epirubicin hydrochloride PDR
Max dose for geriatric 120.0 mg/m2 /dose 120 mg/m2 /dose Ellence epirubicin hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1