Basic Information
| Drug ID | DDPD00444 |
|
| Drug Name | Teniposide | |
| Molecular Weight | 656.654 | |
| Molecular Formula | C32H32O13S | |
| CAS Number | 29767-20-2 | |
| SMILES | [H][C@]12COC(=O)[C@]1([H])[C@H](C1=CC(OC)=C(O)C(OC)=C1)C1=C(C=C3OCOC3=C1)[C@H]2O[C@]1([H])O[C@]2([H])CO[C@H](O[C@@]2([H])[C@H](O)[C@H]1O)C1=CC=CS1 | |
| External Links | ||
| DRUGBANK | DB00444 | |
| T3DB | T3D4715 | |
| PubChem Compound | 452548 | |
| PDR | 24039 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.24 | - | 1.24 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 244.0 | ℃ | 242-246 | ℃ | PhysProp |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 0.62 | L/h/m2 | 10.3 | ml/min/m2 | DRUGBANK | Clearance | 0.0114 | L/h/kg | 0.19 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.41 | L/kg | 0.41 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 5.0 | h | 5 | h | DRUGBANK | Half-life | 16.0 | h | 16 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 5.0 | % | 0-10 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for infants | 250.0 | mg/m2/dose | 250 | mg/m2/dose | intravenous injection, IV | qw | Teniposide | teniposide | PDR |
| Max dose for infants | 165.0 | mg/m2/dose | 165 | mg/m2/dose | intravenous injection, IV | biw | Teniposide | teniposide | PDR |
| Max dose for children | 250.0 | mg/m2/dose | 250 | mg/m2/dose | intravenous injection, IV | qw | Teniposide | teniposide | PDR |
| Max dose for children | 165.0 | mg/m2/dose | 165 | mg/m2/dose | intravenous injection, IV | biw | Teniposide | teniposide | PDR |
| Max dose for adolescents | 250.0 | mg/m2/dose | 250 | mg/m2/dose | intravenous injection, IV | qw | Teniposide | teniposide | PDR |
| Max dose for adolescents | 165.0 | mg/m2/dose | 165 | mg/m2/dose | intravenous injection, IV | biw | Teniposide | teniposide | PDR |
| Max dose for adults | 250.0 | mg/m2/dose | 250 | mg/m2/dose | intravenous injection, IV | qw | Teniposide | teniposide | PDR |
| Max dose for adults | 165.0 | mg/m2/dose | 165 | mg/m2/dose | intravenous injection, IV | biw | Teniposide | teniposide | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1