Basic Information
| Drug ID | DDPD00442 |
|
| Drug Name | Entecavir | |
| Molecular Weight | 277.2792 | |
| Molecular Formula | C12H15N5O3 | |
| CAS Number | 142217-69-4 | |
| SMILES | NC1=NC(=O)C2=C(N1)N(C=N2)[C@H]1C[C@H](O)[C@@H](CO)C1=C | |
| External Links | ||
| DRUGBANK | DB00442 | |
| PubChem Compound | 153941 | |
| PDR | 105 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -0.8 | - | -0.8 | - | DRUGBANK |
| Water Solubility | 2400.0 | mg/L | 2.4 | mg/ml | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 1.0 | h | 0.5-1.5 | h | PO, oral; normal,healthy; | DRUGBANK |
| Clearance | 23.0 | L/h | 383.2±101.8 | ml/min | Renal clearance; normal,healthy; | DRUGBANK | Clearance | 11.9 | L/h | 197.9±78.1 | ml/min | Renal clearance; mild renal function; | DRUGBANK | Clearance | 8.1 | L/h | 135.6±31.6 | ml/min | Renal clearance; moderate renal function; | DRUGBANK | Clearance | 2.4 | L/h | 40.3±10.1 | ml/min | Renal clearance; severe renal function; | DRUGBANK | Clearance | 35.3 | L/h | 588.1±153.7 | ml/min | Total clearance; PO, oral; normal,healthy; | DRUGBANK | Clearance | 18.6 | L/h | 309.2±62.6 | ml/min | Total clearance; PO, oral; mild renal function; | DRUGBANK | Clearance | 13.6 | L/h | 226.3±60.1 | ml/min | Total clearance; PO, oral; moderate renal function; | DRUGBANK | Clearance | 6.0 | L/h | 100.6±29.1 | ml/min | Total clearance; PO, oral; severe renal function; | DRUGBANK | Clearance | 3.0 | L/h | 50.6±16.5 | ml/min | Total clearance; PO, oral; severe renal function; | DRUGBANK | Clearance | 2.1 | L/h | 35.7±19.6 | ml/min | Total clearance; PO, oral; severe renal function; | DRUGBANK |
| Half-life | 2.3 | h | 128-149 | min | elimination half-life; | DRUGBANK | Half-life | 15.0 | h | 15 | h | Metabolite; | DRUGBANK |
| Protein Binding | 13.0 | % | ~13 | % | high protein binding; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 1.0 | mg/day | 1 | mg/day | PO, oral | Baraclude | entecavir | PDR |
| Max dose for children | 0.9 | mg/day | 0.9 | mg/day | Liquid | Baraclude | entecavir | PDR |
| Max dose for children | 0.8 | mg/day | 0.8 | mg/day | Liquid | Baraclude | entecavir | PDR |
| Max dose for children | 0.7 | mg/day | 0.7 | mg/day | Liquid | Baraclude | entecavir | PDR |
| Max dose for children | 0.6 | mg/day | 0.6 | mg/day | Liquid | Baraclude | entecavir | PDR |
| Max dose for children | 0.5 | mg/day | 0.5 | mg/day | Liquid | Baraclude | entecavir | PDR |
| Max dose for children | 0.4 | mg/day | 0.4 | mg/day | Liquid | Baraclude | entecavir | PDR |
| Max dose for children | 0.3 | mg/day | 0.3 | mg/day | Liquid | Baraclude | entecavir | PDR |
| Max dose for adolescents | 1.0 | mg/day | 1 | mg/day | PO, oral | Baraclude | entecavir | PDR |
| Max dose for adolescents | 1.0 | mg/day | 1 | mg/day | PO, oral | Baraclude | entecavir | PDR |
| Max dose for adolescents | 0.9 | mg/day | 0.9 | mg/day | Liquid | Baraclude | entecavir | PDR |
| Max dose for adolescents | 0.8 | mg/day | 0.8 | mg/day | Liquid | Baraclude | entecavir | PDR |
| Max dose for adults | 1.0 | mg/day | 1 | mg/day | PO, oral | Baraclude | entecavir | PDR |
| Max dose for geriatric | 1.0 | mg/day | 1 | mg/day | PO, oral | Baraclude | entecavir | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1