Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00441 ...
Drug Name Gemcitabine
Molecular Weight 263.1981
Molecular Formula C9H11F2N3O4
CAS Number 95058-81-4
SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@@H](O)C1(F)F
External Links
DRUGBANK DB00441
PubChem Compound 60750
PDR 2518
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -1.4 - -1.4 - DRUGBANK
Melting Point 168.64 ℃ 168.64 ℃ DRUGBANK
pKa 3.6 - 3.6 - DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
C Max 7080028.9 ng/ml 26.9±9 mM intravenous infusion, IV in drop; The Pharmacological Basis of Therapeutics
Clearance 84.0 L/h/m2 75.7-92.2 L/h/m2 Male, men; adults; DRUGBANK
Clearance 47.9 L/h/m2 40.7-55.1 L/h/m2 Male, men; Elderly; DRUGBANK
Clearance 63.2 L/h/m2 57-69.4 L/h/m2  Female, women; adults; DRUGBANK
Clearance 36.1 L/h/m2 30.7-41.5 L/h/m2  Female, women; Elderly; DRUGBANK
Clearance 2.3 L/h/kg 37.8±19.4 ml/min/kg Elderly ↓ ; The Pharmacological Basis of Therapeutics
Clearance 1.9 L/h/kg 32 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 50.0 L/m2 50.0 L/m2 intravenous infusion, IV in drop; DRUGBANK
Volume of Distribution 370.0 L/m2 370.0 L/m2 intravenous infusion, IV in drop; Oral multiple dose; DRUGBANK
Volume of Distribution 1.4 L/kg 1.4±1.3 L/kg The Pharmacological Basis of Therapeutics
Volume of Distribution 1.5 L/kg 1.5 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 1.1 h 42-94 min DRUGBANK
Half-life 7.4 h 245-638 min DRUGBANK
Half-life 0.63 h 0.63±0.48 h Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 1.0 h 1 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 500.0 mg/kg 500.0 mg/kg PO, oral; mouse; Rattus, Rat; DRUGBANK
Eliminate Route 95.0 % 92-98 % DRUGBANK
Eliminate Route 10.0 % <10 % Urinary excretion; leukemia; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 10.0 % <10 % plasma proteins; DRUGBANK
Protein Binding 0 % ~0 % leukemia; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for adolescents 1250.0 mg/m2 1250 mg/m2 intravenous injection, IV qw Gemzar gemcitabine PDR
Max dose for geriatric 1250.0 mg/m2 1250 mg/m2 intravenous injection, IV qw Gemzar gemcitabine PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1