Basic Information
| Drug ID | DDPD00434 |
|
| Drug Name | Cyproheptadine | |
| Molecular Weight | 287.3981 | |
| Molecular Formula | C21H21N | |
| CAS Number | 129-03-3 | |
| SMILES | CN1CCC(CC1)=C1C2=CC=CC=C2C=CC2=CC=CC=C12 | |
| External Links | ||
| DRUGBANK | DB00434 | |
| T3DB | T3D2790 | |
| PubChem Compound | 2913 | |
| PDR | 2646 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 4.69 | - | 4.69 | - | SANGSTER (1993) |
| Melting Point | 112.65 | ℃ | 112.3-113.3 | ℃ | Engelhardt, E.L.; U S . Patent 3,014,911; December 26, 1961; assigned to Merck & Co., Inc. |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Eliminate Route | 11.0 | % | 2-20 | % | Faeces excretion; Oral single dose; normal,healthy; human, homo sapiens; | DRUGBANK | Eliminate Route | 40.0 | % | >40 | % | Urinary excretion; Oral single dose; normal,healthy; human, homo sapiens; | DRUGBANK |
| Protein Binding | 97.5 | % | 96-99 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 0.0 | 0 | Cyproheptadine Hydrochloride Syrup | cyproheptadine hydrochloride | PDR | |||
| Max dose for children | 16.0 | mg/day | 16 | mg/day | PO, oral | Cyproheptadine Hydrochloride Syrup | cyproheptadine hydrochloride | PDR |
| Max dose for children | 12.0 | mg/day | 12 | mg/day | PO, oral | Cyproheptadine Hydrochloride Syrup | cyproheptadine hydrochloride | PDR |
| Max dose for adolescents | 0.5 | mg/kg/day | 0.5 | mg/kg/day | PO, oral | Cyproheptadine Hydrochloride Syrup | cyproheptadine hydrochloride | PDR |
| Max dose for adolescents | 32.0 | mg/day | 32 | mg/day | PO, oral | Cyproheptadine Hydrochloride Syrup | cyproheptadine hydrochloride | PDR |
| Max dose for adolescents | 16.0 | mg/day | 16 | mg/day | PO, oral | Cyproheptadine Hydrochloride Syrup | cyproheptadine hydrochloride | PDR |
| Max dose for adults | 0.5 | mg/kg/day | 0.5 | mg/kg/day | PO, oral | Cyproheptadine Hydrochloride Syrup | cyproheptadine hydrochloride | PDR |
| Max dose for adults | 32.0 | mg/day | 32 | mg/day | PO, oral | Cyproheptadine Hydrochloride Syrup | cyproheptadine hydrochloride | PDR |
| Max dose for geriatric | 0.5 | mg/kg/day | 0.5 | mg/kg/day | PO, oral | Cyproheptadine Hydrochloride Syrup | cyproheptadine hydrochloride | PDR |
| Max dose for geriatric | 32.0 | mg/day | 32 | mg/day | PO, oral | Cyproheptadine Hydrochloride Syrup | cyproheptadine hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1