Basic Information
| Drug ID | DDPD00433 |
|
| Drug Name | Prochlorperazine | |
| Molecular Weight | 373.943 | |
| Molecular Formula | C20H24ClN3S | |
| CAS Number | 58-38-8 | |
| SMILES | CN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(Cl)C=C3)CC1 | |
| External Links | ||
| DRUGBANK | DB00433 | |
| T3DB | T3D2789 | |
| PubChem Compound | 4917 | |
| PDR | 1258 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 4.88 | - | 4.88 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 228.0 | ℃ | 228 | ℃ | PhysProp |
| Water Solubility | 15.0 | mg/L | 15 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| pKa | 8.1 | - | 8.1 | - | SANGSTER (1994) |
| Log S | -4.4 | - | -4.4 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 12.5 | % | 12.5 | % | DRUGBANK | |
| T Max | 5.0 | h | 5 | h | DRUGBANK | T Max | 168.0 | h | 7 | day | Oral multiple dose; | DRUGBANK |
| Clearance | 0.98 | L/h/kg | ~0.98 | L/h/kg | Plasma clearance; intravenous injection, IV; normal,healthy; | DRUGBANK | Clearance | 0.0236 | L/h | 23.6 | ml/h | Renal clearance; intravenous injection, IV; normal,healthy; | DRUGBANK | Clearance | 0.96 | L/h/kg | 16 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1401.0 | L | 1401.0 | L | Apparent volume of distribution; intravenous injection, IV; normal,healthy; | DRUGBANK | Volume of Distribution | 1548.0 | L | 1548.0 | L | Apparent volume of distribution; intravenous injection, IV; normal,healthy; | DRUGBANK | Volume of Distribution | 22.0 | L/kg | 22 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 9.0 | h | 9 | h | elimination half-life; intravenous injection, IV; | DRUGBANK | Half-life | 8.0 | h | 8 | h | elimination half-life; Oral single dose; | DRUGBANK | Half-life | 9.0 | h | 9 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 750.0 | mg/kg | 750.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 400.0 | mg/kg | 400.0 | mg/kg | PO, oral; mouse; | T3DB |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 15.0 | mg/day | 15 | mg/day | PO, oral;Rectal Administration; | Prochlorperazine Maleate | prochlorperazine maleate | PDR |
| Max dose for children | 25.0 | mg/day | 25 | mg/day | PO, oral | Prochlorperazine Maleate | prochlorperazine maleate | PDR |
| Max dose for children | 10.0 | mg/day | 10 | mg/day | PO, oral;Rectal Administration; | Prochlorperazine Maleate | prochlorperazine maleate | PDR |
| Max dose for children | 25.0 | mg/day | 25 | mg/day | PO, oral | Prochlorperazine Maleate | prochlorperazine maleate | PDR |
| Max dose for children | 15.0 | mg/day | 15 | mg/day | PO, oral;Rectal Administration; | Prochlorperazine Maleate | prochlorperazine maleate | PDR |
| Max dose for children | 20.0 | mg/day | 20 | mg/day | PO, oral | Prochlorperazine Maleate | prochlorperazine maleate | PDR |
| Max dose for children | 10.0 | mg/day | 10 | mg/day | PO, oral;Rectal Administration; | Prochlorperazine Maleate | prochlorperazine maleate | PDR |
| Max dose for children | 20.0 | mg/day | 20 | mg/day | PO, oral | Prochlorperazine Maleate | prochlorperazine maleate | PDR |
| Max dose for children | 7.5 | mg/day | 7.5 | mg/day | PO, oral;Rectal Administration; | Prochlorperazine Maleate | prochlorperazine maleate | PDR |
| Max dose for children | 20.0 | mg/day | 20 | mg/day | PO, oral | Prochlorperazine Maleate | prochlorperazine maleate | PDR |
| Max dose for adolescents | 50.0 | mg/day | 50 | mg/day | Rectal Administration | Prochlorperazine Maleate | prochlorperazine maleate | PDR |
| Max dose for adolescents | 40.0 | mg/day | 40 | mg/day | PO, oral | Prochlorperazine Maleate | prochlorperazine maleate | PDR |
| Max dose for adolescents | 40.0 | mg/day | 40 | mg/day | IM,intramuscular injection | Prochlorperazine Maleate | prochlorperazine maleate | PDR |
| Max dose for adults | 50.0 | mg/day | 50 | mg/day | Rectal Administration | Prochlorperazine Maleate | prochlorperazine maleate | PDR |
| Max dose for adults | 40.0 | mg/day | 40 | mg/day | PO, oral | Prochlorperazine Maleate | prochlorperazine maleate | PDR |
| Max dose for adults | 40.0 | mg/day | 40 | mg/day | IM,intramuscular injection | Prochlorperazine Maleate | prochlorperazine maleate | PDR |
| Max dose for elderly | 50.0 | mg/day | 50 | mg/day | Rectal Administration | Prochlorperazine Maleate | prochlorperazine maleate | PDR |
| Max dose for elderly | 40.0 | mg/day | 40 | mg/day | PO, oral | Prochlorperazine Maleate | prochlorperazine maleate | PDR |
| Max dose for elderly | 40.0 | mg/day | 40 | mg/day | IM,intramuscular injection | Prochlorperazine Maleate | prochlorperazine maleate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1