Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00425 ...
Drug Name Zolpidem
Molecular Weight 307.3895
Molecular Formula C19H21N3O
CAS Number 82626-48-0
SMILES CN(C)C(=O)CC1=C(N=C2C=CC(C)=CN12)C1=CC=C(C)C=C1
External Links
DRUGBANK DB00425
T3DB T3D2787
PubChem Compound 5732
PDR 1780
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.02 - 3.02 - http://www.t3db.ca/toxins/T3D2787
Melting Point 195.0 ℃ 193-197 ℃ MSDS
Water Solubility 23000.0 mg/L 23 mg/ml MSDS
pKa 5.65 - 5.65 - http://foodb.ca/compounds/FDB023594

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 72.0 % 72±7 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 59.0 ng/ml 59.0 ng/ml DRUGBANK
C Max 121.0 ng/ml 121.0 ng/ml DRUGBANK
C Max 107.5 ng/ml 76-139 ng/ml Oral single dose; adults; young; The Pharmacological Basis of Therapeutics
T Max 1.6 h 1.6 h DRUGBANK
T Max 1.6 h 1.6 h DRUGBANK
T Max 1.8 h 1.0-2.6 h Oral single dose; adults; young; The Pharmacological Basis of Therapeutics
Clearance 0.0153 L/h/kg 0.24-0.27 ml/min/kg Total clearance; DRUGBANK
Clearance 0.27 L/h/kg 4.5±0.7 ml/min/kg hydrolysis; Children ↑ ;Elderly ↓ ;Hepatic cirrhosis, cirr ↓ ;RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Clearance 0.26 L/h/kg 4.3 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.61 L/kg 0.54-0.68 L/kg human, homo sapiens; RD, renal impairment, Renal disease，including uremia ↑ ; DRUGBANK
Volume of Distribution 0.68 L/kg 0.68±0.06 L/kg RD, renal impairment, Renal disease，including uremia ↑ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.54 L/kg 0.54 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.6 h 2.6 h elimination half-life; DRUGBANK
Half-life 2.5 h 2.5 h elimination half-life; DRUGBANK
Half-life 1.9 h 1.9±0.2 h Children ↓ ;Hepatic cirrhosis, cirr ↑ ;RD, renal impairment, Renal disease，including uremia → ;Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 1.7 h 1.7 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 695.0 mg/kg 695.0 mg/kg PO, oral; male rat; DRUGBANK
Toxicity LD50 695.0 mg/kg 695.0 mg/kg PO, oral; Rattus, Rat; T3DB
Eliminate Route 1.0 % <1 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 92.5 % 92.5±0.1 % DRUGBANK
Protein Binding 92.0 % 92 % RD, renal impairment, Renal disease，including uremia ↓ ;Hepatic cirrhosis, cirr ↓ ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 10.0 mg/day 10 mg/day Tablet,PO，oral Edluar zolpidem tartrate PDR
Max dose for adults 10.0 mg/day 10 mg/day sublingual spray Edluar zolpidem tartrate PDR
Max dose for adults 10.0 mg/day 10 mg/day Tablet,PO，oral Edluar zolpidem tartrate PDR
Max dose for adults 12.5 mg/day 12.5 mg/day Tablet,PO，oral Edluar zolpidem tartrate PDR
Max dose for adults 10.0 mg/day 10 mg/day sublingual Edluar zolpidem tartrate PDR
Max dose for adults 1.75 mg /night 1.75 mg /night sublingual Edluar zolpidem tartrate PDR
Max dose for adults 3.5 mg /night 3.5 mg /night sublingual Edluar zolpidem tartrate PDR
Max dose for geriatric 5.0 mg/day 5 mg/day Tablet,PO，oral Edluar zolpidem tartrate PDR
Max dose for geriatric 5.0 mg/day 5 mg/day sublingual spray Edluar zolpidem tartrate PDR
Max dose for geriatric 6.25 mg/day 6.25 mg/day Tablet,PO，oral Edluar zolpidem tartrate PDR
Max dose for geriatric 5.0 mg/day 5 mg/day sublingual Edluar zolpidem tartrate PDR
Max dose for geriatric 1.75 mg/day 1.75 mg/night sublingual Edluar zolpidem tartrate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1