Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00424 ...
Drug Name Hyoscyamine
Molecular Weight 289.3694
Molecular Formula C17H23NO3
CAS Number 101-31-5
SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)[C@H](CO)C1=CC=CC=C1
External Links
DRUGBANK DB00424
T3DB T3D3096
PubChem Compound 154417
PDR 2489
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.8 - 1.8 - DRUGBANK
Melting Point 108.5 ℃ 108.5 ℃ PhysProp
Water Solubility 3560.0 mg/L 3560 mg/L MERCK INDEX 1996); pH 9.5
pKa 11.7 - 11.7 - MERCK INDEX (1996)
Log S -1.91 - -1.91 - ADME Research, USCD

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Absorption 100.0 % 100.0 % PO, oral; DRUGBANK
Half-life 2.8 h 2-3.5 h DRUGBANK
Toxicity LD50 95.0 mg/kg 95.0 mg/kg intravenous injection, IV; mouse; DRUGBANK
Protein Binding 50.0 % 50 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for infants 48.0 drop/day 48 drop/day Liquid Levsin Tablets hyoscyamine sulfate PDR
Max dose for infants 36.0 drop/day 36 drop/day Liquid Levsin Tablets hyoscyamine sulfate PDR
Max dose for infants 30.0 drop/day 30 drop/day Liquid Levsin Tablets hyoscyamine sulfate PDR
Max dose for infants 24.0 drop/day 24 drop/day Liquid Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 4.0 tablets/day 4 tablets/day Tablet,PO，oral Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 1.5 mg/day 1.5 mg/day PO, oral Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 2.0 tablets/day 2 tablets/day Tablet,PO，oral Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 0.75 mg/day 0.75 mg/day PO, oral Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 0.005 mg/kg/dose 5 mcg/kg/dose subcutaneous injection, SC;IM,intramuscular injection;intravenous infusion, iv in drop; Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 2.0 tablets/day 2 tablets/day Tablet,PO，oral Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 0.563 mg/day 0.563 mg/day Liquid Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 0.75 mg/day 0.75 mg/day PO, oral Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 0.005 mg/kg/dose 5 mcg/kg/dose subcutaneous injection, SC;IM,intramuscular injection;intravenous infusion, iv in drop; Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 2.0 tablets/day 2 tablets/day Tablet,PO，oral Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 0.375 mg/day 0.375 mg/day Liquid Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 0.75 mg/day 0.75 mg/day PO, oral Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 0.005 mg/kg/dose 5 mcg/kg/dose subcutaneous injection, SC;IM,intramuscular injection;intravenous infusion, iv in drop; Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 2.0 tablets/day 2 tablets/day Tablet,PO，oral Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 0.188 mg/day 0.188 mg/day Liquid Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 0.75 mg/day 0.75 mg/day PO, oral Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 0.005 mg/kg/dose 5 mcg/kg/dose subcutaneous injection, SC;IM,intramuscular injection;intravenous infusion, iv in drop; Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 48.0 drop/day 48 drop/day Liquid Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 36.0 drop/day 36 drop/day Liquid Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 30.0 drop/day 30 drop/day Liquid Levsin Tablets hyoscyamine sulfate PDR
Max dose for children 24.0 drop/day 24 drop/day Liquid Levsin Tablets hyoscyamine sulfate PDR
Max dose for adolescents 4.0 tablets/day 4 tablets/day Tablet,PO，oral Levsin Tablets hyoscyamine sulfate PDR
Max dose for adolescents 1.5 mg/day 1.5 mg/day PO, oral Levsin Tablets hyoscyamine sulfate PDR
Max dose for adults 4.0 tabLets/day 4 tabLets/day Tablet,PO，oral Levsin Tablets hyoscyamine sulfate PDR
Max dose for adults 1.5 mg/day 1.5 mg/day PO, oral Levsin Tablets hyoscyamine sulfate PDR
Max dose for geriatric 4.0 tablets/day 4 tablets/day Tablet,PO，oral Levsin Tablets hyoscyamine sulfate PDR
Max dose for geriatric 1.5 mg/day 1.5 mg/day PO, oral Levsin Tablets hyoscyamine sulfate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1