Basic Information
| Drug ID | DDPD00417 |
|
| Drug Name | Phenoxymethylpenicillin | |
| Molecular Weight | 350.39 | |
| Molecular Formula | C16H18N2O5S | |
| CAS Number | 87-08-1 | |
| SMILES | [H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)COC1=CC=CC=C1)C(O)=O | |
| External Links | ||
| DRUGBANK | DB00417 | |
| PubChem Compound | 6869 | |
| PDR | 1588 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.09 | - | 2.09 | - | HANSCH,C ET AL. (1995) |
| Water Solubility | 1000.0 | mg/L | <0.1 | g/100ml | DRUGBANK |
| pKa | 2.79 | - | 2.79 | - | SANGSTER (1994) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Bioavailability | 42.5 | % | 25-60 | % | DRUGBANK | ||
| C Max | 450.0 | ng/ml | 200-700 | ng/ml | PO, oral; | DRUGBANK | C Max | 4000.0 | ng/ml | 3-5 | ug/ml | DRUGBANK |
| T Max | 2.0 | h | 2 | h | PO, oral; | DRUGBANK | T Max | 0.75 | h | 0.5-1 | h | DRUGBANK |
| Metabolic | 52.5 | % | 35-70 | % | Inactive metabolite; Urinary excretion; | DRUGBANK | |
| Clearance | 0.41 | L/h/kg | 6.8 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset | |
| Volume of Distribution | 35.4 | L | 35.4 | L | at steady state; intravenous injection, IV; | DRUGBANK | Volume of Distribution | 0.41 | L/kg | 0.41 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 0.50 | h | ~30 | min | PO, oral; | DRUGBANK | Half-life | 4.0 | h | 4 | h | RD, renal impairment, Renal disease，including uremia; | DRUGBANK | Half-life | 0.84 | h | 0.84 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 1040.0 | mg/kg | >1040 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | |
| Eliminate Route | 25.0 | % | 25 | % | Urinary excretion; Infants; Children; | renal insufficiency → ; | DRUGBANK |
| Protein Binding | 65.0 | % | ~50-80 | % | plasma proteins; PO, oral; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 75.0 | mg/kg/day | 75 | mg/kg/day | PO, oral | Penicillin V Potassium | penicillin V potassium | PDR |
| Max dose for infants | 75.0 | mg/kg/day | 75 | mg/kg/day | PO, oral | Penicillin V Potassium | penicillin V potassium | PDR |
| Max dose for children | 2000.0 | mg/day | 2 | g/day | PO, oral | Penicillin V Potassium | penicillin V potassium | PDR |
| Max dose for children | 75.0 | mg/kg/day | 75 | mg/kg/day | PO, oral | Penicillin V Potassium | penicillin V potassium | PDR |
| Max dose for children | 2000.0 | mg/day | 2 | g/day | PO, oral | Penicillin V Potassium | penicillin V potassium | PDR |
| Max dose for adolescents | 2000.0 | mg/day | 2 | g/day | PO, oral | Penicillin V Potassium | penicillin V potassium | PDR |
| Max dose for adults | 2000.0 | mg/day | 2 | g/day | PO, oral | Penicillin V Potassium | penicillin V potassium | PDR |
| Max dose for geriatric | 2000.0 | mg/day | 2 | g/day | PO, oral | Penicillin V Potassium | penicillin V potassium | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1